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Unit 2 Pharm III > Major adverse effects > Flashcards

Major adverse effects Flashcards

1
Q

Theophylline

A

High dose is toxic
Low dose ineffective
very narrow therapeutic range
(drug of last choice)

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2
Q

Oral candidiasis

A

inhaled corticosteroids

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3
Q

CNS stimulation side effects

A

Theophylline

think similar to caffeine

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4
Q

Celecoxib

A

CVD caused by imbalance of Thromboxane > Prostacyclin

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5
Q

Acetaminophen

A

Dose dependent fatal hepatic necrosis

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6
Q

ASA + children

A

Reye’s syndrome if they have a virus (cerebral edema)

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7
Q

Milk alkali syndrome

A

Calcium carbonate + dairy

Hypercalcemia with renal insufficiency and metabolic acidosis

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8
Q

PPIs

A

Osteoporosis from decreased Ca++ absorption

C diff

URIs

Pneumonia

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9
Q

Long term use of a PPI

A

Reduced absorption of Calcium, magnesium, B12

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10
Q

Misoprostol + pregnancy

A

Abortion drug, always contraindicated

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11
Q

Similar to antipsychotics so it can cause EPS

A

Metopramide

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12
Q

Methemoglobinemia in infants

A

Metopramide

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13
Q

GI drugs with antimuscarinic side effects

A

Glycopyrrolate

Dicylomine

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14
Q

Bad for CHF

A 
Sodium bicarbonate (antacid)
Sodium salt enema
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15
Q

Laxative overuse causes

A

Electrolyte imbalance

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16
Q

Vasoconstriction severe enough to make limbs fall off

A

chronic ergot use

17
Q 
Bone marrow damage
Dermatitis
Enterocolitis
Jaundice
Peripheral neuropathy
A

Gold salts

18
Q

Penicillamine is highly toxic:

A

Pruritus, rash, alteration in taste.

Thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.

Proteinuria, hypoalbuminemia, nephrotic syndrome.
Lupus like disease, pemphigus, Goodpasture’s syndrome, myasthenia gravis, polymyositis, stenosing alveolitis.

19
Q 
Pruritus
Ototoxicity
Retinopathy
Peripheral neuropathy
G6PD deficient→ hemolysis
A

Hydroxychloroquine

20
Q

Worst immunosuppression, worst risk of infection and malignancies

A

Tocilizumab

Unit 2 Pharm III (8 decks)

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