Drug Interactions Flashcards
Inhibit the metabolism of theophylline, causing toxicity
Cimetidine
Ketoconazole
Erythromycin
Extensively bound to plasma proteins→ displacement→ drug reactions: oral anticoagulants, hypoglycemic agents
Naproxen
(think of its long half life)
anticoagulants=warfarin
Alcohol + Acetaminophen
Alcoholism induces P450s, increased production of toxic metabolites causes liver damage
Ibuprofen + ASA
Ibuprofen inhibits the binding of aspirin, decreasing its effects on platelet aggregation
Aspirin competes for protein plasma binding sites with _____
thyroxine T3 Penicillin-G thiopental bilirubin phenytoin sulfinpyrazone naproxen warfarin (bleeding)
Aspirin + Antacids
antacids increase pH and decrease ASA absorption
Cimetidine inhibits _____ causing tons of drug interations
CYP3A4: Warfarin Phenytoin Theophylline Digoxin
Antacids form insoluble complexes with
Theophylline
Ketoconazole
Quinolone antibiotics
Tetracycline
Antacids decrease the absorption of ____
Digoxin
Phenytoin
Propranolol
Antacids increase elimination of ______ by alkalinizing urine
Phenobarbital
Salicylates
Omeprazole inhibits ______ and interacts with _____, but its rarely a big deal
CYP2C19
Phenytoin
Warfarin
Diazepam
Clopidogrel
Probenecid decreases the excretion of ____
Penicillin
Methotrexate
Clofibrate
Glucoronides of NSAIDS
Allopurinol (and febuxostat?) make _____ more effective and _____ less effective
More: 6 mercaptopurine, azathiorpine
Less: 5 FU
Acidic drugs + gout
Acidic drugs compete for excretion by OAT and so more uric acid accumulates
