main points of biochem

Question 1

pt with

garlic breath

vomiting

rice water stools

QT prolongation

Answer 1

arsenic poisoning.

arsenic inhibits lipoic acid. which is needed for pyruvate dehydrogenase complex.

Question 2

tx for

pyruvate dehydrogenase def

Answer 2

ketogenic amino acids

(**Lysine, leucine)

vit supplementation if its caused by

vit B def (thiamine)

“Lysine and Leucine - the onLy pureLy ketogenic AA)

Question 3

what is the rate limiting enzyme for TCA cycle

Answer 3

Isocitrate dehydrogenase

isocitrate –> a-ketoglutarate

Question 4

what are the 3 key enzymes you need to know for TCA cycle?

Answer 4

citrate synthase

isocitrate dehydrogenase

a-ketoglutarate dehydrogenase

Question 5

what 4 end products can be made from pyruvate

Answer 5

oxaloacetate

lactate

acetyl-CoA

Alanine

Question 6

what 4 B vitamins are needed to make cofactor for pyruvate dehydrogenase

Answer 6

B1 (thiamine) –> TTP

B2 (riboflavin) –> FAD+

B3 (niacin) –> NAD+

B5 (pantothenic acid) –> Co enzyme A

Question 7

cause of

familial hypercholesteralemia

Answer 7

def of

LDL receptors

Question 8

which apolipoprotein matches the statement

activates LCAT

Answer 8

ApoA-1

Question 9

which apolipoprotein matches the statement?

mediates Chylomicron secretion

Answer 9

ApoB-48

Question 10

which apolipoprotein matches the statement

mediates VLDL secretion

Answer 10

ApoB-100

Question 11

which apolipoprotein matches the statement

cofactor for lipoprotein lipase

Answer 11

ApoC-II

Question 12

which apolipoprotein matches the statement

mediates uptake of remnant particles

Answer 12

ApoE