MAIN DRUG INTERACTIONS Flashcards
What drugs can cause hepatotoxicity?
- alcohol
- atorvastatin
- carbamazepine
- doxycycline
- fluclox
- fluconazole
- fluvastatin
- isoniazid
- itraconazole
- leflunomide
- methotrexate
- mercaptopurine
- paracetamol
- pravastatin
- simvastatin
- rosuvastatin
- sulfasalazine
- valproate
- vincristine
What drugs can cause nephrotoxicity?
- aciclovir
- amphotericin B
- cefalexin and the cephalosporin drug class
- celecoxib
- ciclosporin
- cisplatin
- diclofenac
- gentamicin
- ibuprofen
- indomethacin
- meloxicam
- methotrexate
- neomycin
- tacrolimus
- timethoprim
- vancomycin
- zoledronate
What drugs can cause an anticoagulant effect? These drugs can increase the risk of bleeding; concurrent use of drugs with an antiplatelet effect might also increase the risk.
- alteplase
- DOACs
- bivalirudin
- enoxaparin
- heparin
- nicotinic acid
- phenindione
- streptokinase
- warfarin
What drugs can cause an antiplatelet effect?
- aspirin
- celecoxib
- citalopram
- clopidogrel
- diclofenac
- dipyridamole
- duloxetine
- ibuprofen
- sertraline
- venlafaxine
- ticagrelor
What drugs can cause thromboembolism?
- cyclophosphamide
- doxorubicin
- darbepoetin alfa
- fluorouracil
- methotrexate
- strontium
- tamoxifen
- thalidomide
- tibolone
- tranexamic acid
- tretinoin
- vinblastine
- vincristine
What drugs can cause bradycardia?
- alfentanil
- amiodarone
- atenolol
- bisoprolol
- clonidine
- digoxin
- diltiazem
- donepezil
- fentanyl
- flecainide
- ivabradine
- methadone
- neostigmine
- selegiline
- timolol
- verapamil
What drugs can cause FIRST DOSE hypotension?
- alfuzosin
- ARBs
- doxazosin
- ACEi
- glycerol trinitrate & nitrates
- tamsulosin
What drugs can cause hypotension?
- alcohol
- amitriptyline
- CCB
- aripiprazole
- BB
- ACEi
- ARB
- diuretics
- SGLT2i
- nitrates
- haloperidol
- levodopa
- nicorandil
- olanzapine
- quetiapine
- phenelzine
- risperidone
- sildenafil
- tamsulosin
What drugs can prolong the QT interval? Increasing age, female sex, cardiac disease, and some metabolic disturbances (notably hypokalaemia) predispose to QT prolongation.
- amiodarone
- amisulpride
- citalopram
- clarithromycin
- flecainide
- fluconazole
- levomepromazine
- Li
- methadone
- ondansetron
- quinine
- sildenafil
- sotalol
- tolterodine
- venlafaxine
- voriconazole
What drugs can cause antimuscarinic effects?
- amantadine
- amitriptyline
- atropine
- baclofen
- chlorphenamine
- chlorpromazine
- clozapine
- cyclizine
- clomipramine
- dosulepin
- fesoterodine
- glycopyrronium
- haloperidol
- hydroxyzine
- hyoscine
- imipramine
- ipratropium
- nefopam
- oxybutynin
- solifenacin
- umeclidinium
What drugs can cause CNS depressant effects?
- alcohol
- amitriptyline
- aripiprazole
- baclofen
- buprenorphine
- cannabidiol
- chlordiazepoxide
- chlorphenamine
- cinnarizine
- clobazam
- clonazepam
- clonidine
- codeine
- clozapine
- diamorphine
- gabapentin
- haloperidol
- lorazepam
- mirtazapine
- quetiapine
- venlafaxine
What drugs cause peripheral neuropathy?
- amiodarone
- cisplatin
- disulfiram
- doxetaxal
- isoniazid
- metronidazole
- nitrofurantoin
- phenytoin
- vincristine
What drugs can cause serotonin syndrome?
- SSRIs
- fentanyl
- imipramine
- Li
- methadone
- ondansetron
- selegiline
- St John’s Wort
- sumatriptan
- venlafaxine
What drugs are antidiabetic drugs? Concurrent use of these can increase the risk of hypoglycaemia.
- Metformin
- Pioglitazone
- Acarbose
- Sulphonylureas - gliclazide
- DPP-4i
- Meglitinides
- SGLT-2i
- GLP-1 agonists
What drugs can cause myelosuppression?
- azathioprine
- bleomycin
- busulfan
- carboplatin
- chlorambucil
- cisplatin
- cyclophosphamide
- taxanes
- fluorouracil
- methotrexate
- peginterferon alfa
- sulfasalazine
- vincristine
