Chemotherapy Flashcards
1
Q
Which cytotoxic drugs can cause otoxocity and nephrotoxocity?
A
- Cisplatin
- Carboplatin
2
Q
Which drugs do not cause bone marrow suppression?
A
- Vincristine
- Bleomycin
3
Q
Which drugs can cause peripheral neuropathy?
A
- Vincristine
- Taxanes (docetaxel, paclitaxel)
- Vinca Alkaloids (vincristine, vinblastine) - IV administration, never intrathecally as it can cause severe neurotoxicity
4
Q
Which drugs cause pulmonary fibrosis?
A
- Bleomycin
- Busulfan (alkylating agent)
5
Q
Which drugs cause cardiotoxicity?
A
- Doxorubicin (anthracycline)
- Trastuzumab
6
Q
Which drugs cause haemorrhagic cystitis and urothelial toxicity?
A
- Cyclophosphamide - this is co-treated with MENSA to overcome haemorrhagic cystitis
- ifosfamide (alkylating agent)
7
Q
Which drugs cause myelosuppression?
A
- Methotrexate (can cause renal toxicity issues)
- 5-FU
- 6-MP
8
Q
Which drugs can cause neurotoxic issues?
A
- Nitrosoureas can cross BBB
Carmustine is hepatotoxic and pulmonary toxic!
9
Q
Which drugs are highly emetogenic?
A
- High doses of cyclophosphamide - alkylating agent
- Cisplatin - platinum complex
- Decarbazine (alkylating agent)
10
Q
Which drug can cause a change in visual acuity?
A
Tamoxifen
11
Q
Which drug causes signs of bleeding? (epistaxis)
A
Plicamycin
12
Q
Which drug causes muscle pain, malaise, fever?
A
Cytarabine
