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High Risk Drugs > Antidiabetic drugs > Flashcards

Antidiabetic drugs Flashcards

1
Q

What is diabetes insipidus?

A

The passing of large volumes (>3L/24h) of dilute urine, nocturia, and thirst

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2
Q

How do you treat diabetes insipud?

A

DESMOPRESSIN and maintaining fluid intake
Cranial = vasopressin or DESMOPRESSIN, for when the hypothalamus doesn’t make enough ADH. Desmopressin is a more potent analogue of vasopressin with a longer duration of action and no vasconstrictor effects.
Nephrogenic = thiazide diuretics - a paradoxical effect when the kidneys don’t respond to ADH

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3
Q

What are the cautions to DESMOPRESSIN?

A

Fluid overload, CVD, HF, HTN

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4
Q

What are the monitoring requirements for DESMOPRESSIN?

A

Serum Na levels, urine output, fluid balance

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5
Q

What are the SEs of DESMOPRESSIN?

A

Hyponatraemia, esp if fluid intake is not restricted

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6
Q

What is the MHRA Alert of DESMOPRESSIN?

A
  • risk of severe harm or death when desmopressin is omitted or delayed in pts with cranial DM insipidus. It can happen within hrs.
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7
Q

What are the interactions with DESMOPRESSIN?

A

Increases risk of hyponatraemia meds => SSRIs
Chlorpromazine =>increase risk of hypoNa
Lamotrigine => increase hypoNa

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High Risk Drugs (14 decks)

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