MAHA Flashcards
1
Q
MAHA
Def + causes
A
Fibrin / platelet mesh in small damaged vessels = mechanical RBC destruction (schistocytes)
TTP, HUS, DIC, HELLP
2
Q
Schistocytes
A
MAHA
3
Q
Pentad: MAHA + fever + neuro signs + thrombocytopenia + renal impairment
ADAMST13 inhibited by antibodies = VWF multimers deposit in vessels
A
TTP
4
Q
E coli 015H7
Children + elderly
Petting zoos
Triad: MAHA + diarrhoea + renal failure
A
HUS
5
Q
DIC
A
Disseminated intravascular coagulation
Widespread clotting activation
Subsequent bleeding as platelets + CF used up
Caused by sepsis / trauma / cancer
6
Q
Loss of protective GPI markers on RBCs = complement mediated lysis at night
Morning haemoglobinuria
Ham’s test positive
A
PNH
