Macromolecular Traffic (4.2)

Question 1

What is the ER important in

Answer 1

Lipid and protein biosynthesis

Question 2

What are polysomes

Answer 2

When many ribosomes are attached on the one mRNA

Question 3

What is the function of the SRP

Answer 3

Signals need for attachment of forming polypeptide to the ER

Question 4

Is import of proteins into the ER co-translationally

Answer 4

Yes

Question 5

What is the purpose of BiP

Answer 5

Chaperone assisting in pulling polypeptide out into the lumen

Question 6

Transmembrane proteins exist on?

Answer 6

Both the inside and outside of the ER membrane

Question 7

What assits folding and assembly of ER reisdent proteins

Answer 7

ER resident chaperones, retention signals and protein disulfide isomerase

Question 8

What is glycosylation

Answer 8

Addition of sugar to proteins, allows for signalling and correct folding; interaction with other molecules

Question 9

Where does sugar attach

Answer 9

N-linked oligosaccharide

Question 10

Lipid layer biosynthesis occurs in

Answer 10

The ER

Question 11

Membranes grow by

Answer 11

Insertion of new lipids and proteins made