BIOL340 Research in Proteostasis (3.2) Flashcards
1
Q
What are sHsps?
A
Inhibitors of protein aggregation - particularly amyloid fibril aggregation
2
Q
What is the goal of the PDRC?
A
To work out how sHsps work
3
Q
What do sHsps bind to?
A
mature amyloid fibrils
4
Q
What is fibril binding mediated by?
A
The N/C - Terminal domains of the sHsps
5
Q
What is the affect of sHsp binding?
A
Fibrils become more stable, preventing breakdown into smaller parts
6
Q
What did Mark research
A
Extracellular proteostasis
7
Q
What is clusterin
A
An extracelllular chaperone
8
Q
What does clusterin do?
A
Inhibits in vitro protein aggregation induced by a variety of stress conditions
9
Q
What are features of clusterin?
A
Bind to hydrophobicity; does not require ATP; does not refold proteins
