Macrolides Flashcards
1
Q
What are they used for?
A
- H Pylori
- RTIs
- Skin and soft tissue infection
- Chlamydia
2
Q
What are examples of macrolides?
A
- Azithromycin (OD)
- Clarithromycin (BD)
- Erythromycin (QDS/BD)
- Telithromycin
- Spiramycin
3
Q
Which macrlides need to be taken before food and require a 2 hour gap before taking indigestion remedies?
A
- Azithromyicn
- Erythromycin
4
Q
Which macrolide causes taste disturbances, tooth and tongue discolouration?
A
Clarithromycin
5
Q
What are the general side effects of macrolides?
A
- GI effects - mostly with erythromycin
- QT interval prolongation
- Hepatotoxicity
- Ototoxicity with high doses
6
Q
What interacts with macrolides?
A
- Erythromycin and clarithromycin are enzyme inhibitors
- Warfarin - increased risk of bleeding
- Statins - increased risk of myopathy
