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Pharm Test 2 > Macrolides > Flashcards

Macrolides Flashcards

1
Q

Which Gram + bacteria do Macrolides cover?

A

Staph and Strep (Increasing resistance)
Corynebacteria
mycoplasma, legionella
listeria

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2
Q

Treatment for Chlamydia?

A

FL: Azithromycin
Preggo: Erythromycin
Lymphogranuloma venereum: Erythromycin

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3
Q

Treatment for Pertussis?

A

FL: Clarithromycin
Infants: Azithromycin

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4
Q

Treatment for Diphtheria?

A

Erythromycin

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5
Q

Treatment Campylobacter gastroenteritis (dysentery)

A

SL: Erythromycin

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6
Q

Treatment for H. pylori?

A

FL: Clarithromycin w/ amoxicillin

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7
Q

Treatment for mycobacteria

A

Clarithromycin or Azithromycin for prophylaxis in AIDS ptn

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8
Q

Endocarditis prophylaxis in dental procedures

A

Clarithromycin

Erythromycin

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9
Q

Macrolide ADR

Think three picture slide

A

NVD
Liver
Cardiac, Long QT

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10
Q

How is Erythromycin metabolized?

A

by the hepatic enzyme CYP3A4

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11
Q

What do you need to know about a patient before prescribing erythromycin?

A

Allergies, pregnancy, liver status, cardiac status, other meds

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12
Q

What are the contraindications and warnings for clarithromycin?

A 
hypersensitivity 
hepatic dysfunction (liver), Statins which are metabolized by P450
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13
Q

Uses for Clarithormycin

A

Lyme
Toxoplasmosis
Bacterial endocarditus prophylaxis

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14
Q

How is Clarithromycin excreted?

A

Renal and feces

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15
Q

ADRs for Clarithromycin?

A

NVD

Dysgeusia

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16
Q

Uses for azithromycin?

A

Strep pharyngitis/tonsillitis in PNC allergy pnts

Skin infections

17
Q

Macrolides ADRs skin?

A

SJS

18
Q

Azithormycin ADRs

A

SJS, TEN and CDAD

19
Q

What is the D Test?

A

Clindamycin-susceptible and erythromycin-resistant test

20
Q

What is Clindamycin’s MOA

A

Inhibits protein synthesis by binding 50s robsomal subunit

21
Q

Uses for Clindamycin

A

AOM, pharyngitis, tonsilitis

Bone and joint infxns (Penetrates bone well)

Pharm Test 2 (3 decks)

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