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Pharm Test 2 > Antiretrovirals > Flashcards

Antiretrovirals Flashcards

1
Q

What does NRTI stand for?

A

Nucelotide Reverse Transcriptase Inhibitor

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2
Q

List three NRTIs.

A

Abacavir
Zidovudine
Lamivudine
Emtricitabine

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3
Q

What is the MOA of the NRTIs?

A

Analogs of nucleotides that inhibit nucleotide binding to REVERSE TRANSCRIPTASE and cause DNA chain termination

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4
Q

What are the adverse effects common to the NRTIs?

A

1) Lactic acidosis
2) Fatty liver disease
3) Lipodystrophy

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5
Q

What does NNRTI stand for?

A

Non-Nucleoside reverse transcriptase inhibitors

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6
Q

List three NNRTIs

A

Nevirapine (NVP)
Etravirine (ETR)
Efavirenz (EFV)

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7
Q

What is the MOA of the NNRTIs?

A

Binds to Reverse Transcriptase a site OTHER THAN THE ACTIVE SITE and inhibits the enzyme

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8
Q

What are the adverse effects common to the NNRTIs?

A

Hepatoxicity
Rash (StevensJohnson Syndrome)
Drug Interactions

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9
Q

What does PI stand for?

A

Protease Inhibitors (PIs)

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10
Q

List three PIs

A

Ataznavir (ATV
Darunavir (DRV)
Indinavir (IDV)

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11
Q

What are the adverse effects common to the PIs

A

Hyperlipidemia
Lipodystrophy
Hepatotoxcity
Drug-Drug interactions

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12
Q

What is the MOA of PIs?

A

Block the protease necessary for maturation of virion proteins

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13
Q

What does II stand for?

A

Integrase Inhibitors

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14
Q

List three IIs

A

Dolutegravir (DTG)
Raltegravir (RAL)
Ellvitegravir/cobicistat (EVG/c)

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15
Q

What is the MOA of IIs?

A

Inhibit viral integration into the host genome

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16
Q

What are the adverse effects common to the IIs?

A

Headache
Insomnia
DKA
Rash

17
Q

What is the MOA for Fusion Inhibitors?

A

Binds HIV enelopeBinds HIV envelope glycoprotein, gp41

Prevents viral fusion with target membrane

18
Q

What are the ADR to Fusion inhibitors?

A

Injection site reactions
Hypersensitivity
Increased risk of bacterial pneumonia

19
Q

Name one fusion inhibitor

A

Enfuvirtide (ENF, T-20)

20
Q

What is the MOA of CCR5 Receptor Antagonists?

A

Block interaction of HIV with CCR5 co-receptor

21
Q

Name one CCR5

A

Maraviroc (MVC)

22
Q

What are the ADRs to CCR5?

A

Drug-drug
Rash
Orthostasis
URI, cough

Pharm Test 2 (3 decks)

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