Macrolides Flashcards
1
Q
Mechanism
A
bind 50s subunit, prevent translocation (bacteriostatic)
2
Q
Adverse effects
A
epigastric distress
cholestatic jaundice (erythromycin)
ototoxicity
3
Q
Contraindications
A
pt with hepatic dysfunction
4
Q
Macrolide drugs
A
Erythromycin
Azithromycin
Clarithromycin
5
Q
Erythromycin uses
A
Used in penicillin allergic pt for streptococcal, pneumonococcal, disseminated gonococcal disease/infections
Treatment/prophylaxis in: Carrier state of C. diphtheria, Chlamydia infection during pregnancy, Pneumonia (L. pneumonophilia, C. trachomatis), respiratory tract infections (M. pneumoniae)
6
Q
Azithromycin uses
A
H. influenzae, M. pneumoniae, C. trachomatis
7
Q
Clarithromycin uses
A
Peptide ulcer (in combination with amoxicillin and gastric acid inhibitor)
