Aminoglycosides Flashcards
1
Q
Aminoglycosides (5)
A
gentamycin neomycin streptomycin tobramycin amikacin
2
Q
Mechanism of action
A
Bind 30s ribosomal s.u.
interfere with initiation and misreading of protein synthesis
3
Q
Adverse effects
A
renal toxicity (reversible) Ototoxicity (cochlear toxicity - cumulative&irreversible; vestibular toxicity - reversible) **Once daily dosing to minimize toxicity
4
Q
Gentamicin uses
A
combine with B-lactam for enterococcal, staphylococcal, or viridians strep (endocaditis)
5
Q
Streptomycin uses
A
MDR-TB, plague, tularemia
6
Q
Tobramyin uses
A
P. aeruginosa (CF)
7
Q
Amikacin uses
A
Treat organisms resistant to other aminoglycosides
8
Q
Synergistic interactions
A
B-lactam penicillins
Use w/ ampicillin/vancomycin to decrease dose & toxicity
