MAB2 Flashcards
Why is Monoclonal AB therapy faster and safer and more specific than PAB
Doesnt need immune system
Interacts w/immune system for ADCC
Name a MAB drug that is bound to a drug
Certolizumab
What is the process called for adding compound via covalent (PEG) to drug for MAB?
Novel Site Specific PEGylation
What does Novel Site Specific PEGylation allow (4)
Increased half life
Improved Pharmokinetics
Potency
Decreased Immune system activation (Dozier 2015)
How does a naked monoclonal AB work?
Binds to specific antigen –> marks for ADCC =control cancer growth
Name a naked monoclonal AB
What does it bind and (inactivate) to and what is it used for?
Herceptin
HER2 (advanced breast cancer)
Name a monoclonal AB thats used for RA (autoimmune disease therapy)
what does it bind to?
Infliximab
TNF-a
Name 3 problems with MAB
High potency
Low immunogenicity for targets
Can cross react w/other tumours
What is the main problem w/murine MAB
what complexes can form as a consequence of MAB
contains a mouse antigen = trigger immune response = therapeutic MAB eliminated
Immune complexes = nephritis
What are the 4 different types of MAB
What % of human are they?
Chimeric (60-70%)
Humanization (90-95%)
Phage display (100%)
Transgenic mice (100%)
What is the structure of Chimeric Humanised AB
What is the process of production
Binding portion of Mouse AB + human AB
DNA expressed via mammalian cell culture
Name a PAB given for RSV patients
When is it specifically given
RespiGam
given IV for ID patients
Name a MAB given for RSV patients
What does it bind to and thus not allow?
Palivizumab
Binds to F protein = No fusion w/cells no syncytium
What % of Palivizumab is human?
95%
