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ABHAYS A-LEVEL BIO FLASHCARDS > M3, C8 Transport in Animals > Flashcards

M3, C8 Transport in Animals Flashcards

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1
Q

What is transport

A

the movement of oxygen, nutrients, hormones, waste and heat around the body.

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2
Q

Why do animals need a transport system?

A

High Metabolic demand, ie need lots of oxygen and food, produce lots of waste, diffusion over long distances is not enough
Small SA:V ratio
Long diffusion distances so need to be able to transport hormones/enzymes quickly
Food digested in one organ, needs to be transported to all cells
Waste products of metabolism need to be removed from cells and excreted

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3
Q

what makes a good transport system?

A

fluid/medium (blood)
a pump
exchange surfaces
tubes/vessels

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4
Q

what is a mass transport system

A

when substances are transported in a mass of fluid with a mechanism for moving the fluid around

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5
Q

what is a closed circulatory system

A

In a closed circulatory system, blood is fully enclosed within blood vessels at all times.
From the heart, blood is pumped through a series of progressively smaller vessels.
In the smallest vessels, capillaries, substances diffuse in and out of the blood and into cells.
Blood then returns to the heart via a series of progressively larger vessels.

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6
Q

Use the example of insects to demonstrate how an open circulatory system works

A

An open circulatory system consists of a heart that pumps a fluid called haemolymph through short vessels and into a large cavity called the haemocoel.
In the haemocoel, the haemolymph directly bathes organs and tissues, enabling the diffusion of substances.
The transport medium is under low pressure.
Haemolymph moves around the haemocoel due to the movement of the organism.
The haemolymph returns to the heart through an open-ended vessel

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7
Q

what are the similarities between the open and closed circularity systems?

A

Liquid transport medium
Vessels to transport the medium
Pumping mechanism to move the fluid

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8
Q

what are the differences between the open and closed circulatory systems?

A

Open has few vessels, closed has a transport medium enclosed in vessels
Open transport medium is pumped into body cavity (haemocoel) under low pressure, in closed heart pumps blood around under high pressure
Blood has a higher rate of flow (moves faster) in open circulatory system
In open, transport medium directly contacts the body cells, in closed no direct contact between medium and cells
In open transport medium returns to heart through open ended vessels in closed blood flows relatively fast and returns to heart all within vessels

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9
Q

what are examples of organisms that have an open circulatory system and organisms with a closed circulatory system

A

Closed:
All vertebrates (fish and mammals)
Open:
Invertebrates (insects)

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10
Q

what is a single circulatory system

A

Blood goes once through the heart for each complete circuit of the body

For example fish – the heart pumps blood to the gills to pick up oxygen and then on through the body to deliver oxygen.

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11
Q

what is a double circulatory system

A

The blood travels twice through the heart for each circuit of the body
For example in mammals – the heart is divided down the middle

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12
Q

what is the advantage with a double circulatory system

A

Blood is pumped at a higher pressure so travels faster

So oxygen is delivered quicker to the cells

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13
Q

what are arteries

A

transport blood away from the heart

blood is pumped out of the heart at high pressure so arteries are structured to withstand and maintain high pressure

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14
Q

what are the 5 general layers found in blood vessels

A 
Collagen 
Smooth Muscle 
Elastic FIbres 
Endothelium 
Lumen
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15
Q

what is the function of the collagen layer in blood vessels

A

Tough collagen fibers are protective and supportive

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16
Q

what is the smooth muscle layer in arteries

A

Allows arteries to expand and constrict
This is useful as it allows them to control the volume of blood reaching an organ.

Smooth muscle and elastic fibers are the thickest layers in arteries

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17
Q

what is the lumen layer in the artery

A

narrow to maintain high blood pressure

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18
Q

How does the collagen and smooth muscle layer in veins compare to that in arteries

A

thinner than arteries because don’t need to withstand high blood pressure

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19
Q

what is the lumen layer in veins

A

relatively large compared to artery because they don’t need to maintain high blood pressure

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20
Q

why do veins need valves

A

to prevent the backflow of blood away from the heart

also help prevent blood from pooling in the lower parts of the body due to gravity

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21
Q

what are capillaries and what are their adaptations

A

branch off from arterioles and are the smallest blood vessels
form capillary beds which function to bring the blood as close to cells as possible to enable the efficient exchange of substances
thin lumen - slows blood flow for diffusion
one cell thick endothelium
basement membrane anchors capillaries in position within tissues

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22
Q

what are arterioles

A

branch off from arteries
similar in structure to arteries but have less elastic tissue and more smooth muscle. this enables them to constrict and reduce blood flow through capillaries

can also vasoconstrict and vasodilate for thermoregulation

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23
Q

what are venules

A

They drain blood from capillary beds and feed it back into veins.

Note they also contain valves

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24
Q

delete card

A

delete card

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25
Q

What is in blood?

A 
consists of plasma containing:
dissolved glucose
amino acids
mineral ions
hormones
proteins (including albumin, globulins and fibrinogen)
red blood cells
white blood cells
platelets
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26
Q

what are platelets and what is their function

A

Fragments of large cells

They form blood clots, sealing off the site of a wound

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27
Q

what is are the 7 functions of blood?

A

To transport:

  • oxygen to, carbon dioxide from, the respiring cells
  • digested food from the small intestine
  • nitrogenous waste products from the cells to the excretory organs
  • chemical messages (hormones)
  • food molecules from storage compounds to the cells that need them
  • platelets to damaged areas
  • cells and antibodies involved in the immune response
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28
Q

what else does blood contribute to

A

maintenance of a steady body temperature and acts as a buffer, minimising pH changes

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29
Q

what is osmosis

A

It is the net movement of water molecules from a region of high water potential to a region of low water potential, through a partially-permeable membrane.

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30
Q

what is tissue fluid

A

The fluid that surrounds cells in tissues
Made from substances that leave the blood plasma (oxygen, glucose, nutrients)
But NO red blood cells or big proteins, they are too big to get through the small holes (fenestrations) in the capillary wall

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31
Q

what is lymph

A

Excess tissue fluid gets returned to the blood through the lymphatic system (10%)
Similar composition to plasma and tissue fluid, but less oxygen and fewer nutrients.

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32
Q

what are the three components of the lymphatic system

A

lymph vessels
lymph capillaries
lymph nodes

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33
Q

what are lymph nodes

A

Found along the lymph vessels, sac-like organs, contain lymphocytes, which produce antibodies to intercept pathogens

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34
Q

compare blood, tissue fluid and lymph

A

only blood has red blood cells
all have white blood cells but tissue fluid has very few
only blood has platelets
Only blood has large plasma proteins
Lymph contains antibodies
all have water and all have dissolved solutes

35
Q

Explain tissue fluid formation in capillaries

A

At the arterial end, hydrostatic pressure is higher than osmotic pressure, so components of blood plasma e.g. oxygen and glucose leave through fenestrations in the capillary endothelium.

Osmotic pressure remains constant throughout the capillary

At the venule end the hydrostatic pressure is now lower than the osmotic pressure so tissue fluid returns down the pressure gradients

36
Q

overall how does blood plasma go to tissue fluid then to lymph and back to the blood plasma?

A

blood plasma to tissue fluid by ultrafiltration
tissue fluid to blood plasma by reabsorption
tissue fluid to lymph by drainage
lymph to blood plasma by lymph vessels

37
Q

how are erythrocytes adapted for carrying lots of oxygen

A

no nucleus or other organelles to carry as much hemoglobin as possible
biconcave to increase surface area
almost same width as capillary - can fit through narrow capillaries
contains haemoglobin to react with 4 oxygen molecules making oxyhaemoglobin

38
Q

what’s the structure of haemoglobin

A

It is a globular protein- hydrophilic interactions on outside, hydrophobic interactions on the inside
Quaternary structure- 4 polypeptide chains, 2 Alpha and 2 Beta Subunits
It contains 4 iron heam groups
Each heam group joins to one oxygen molecule
So in total, 4 oxygen molecules can join to a haemoglobin molecule to form: oxyhaemoglobin

39
Q

Explain why the oxygen dissociation curve takes an S shape

A

shows how much oxygen the haemoglobin has compared to the oxygen available
0% saturation means none of the Hb molecules are carrying any oxygen
when the percentage of oxygen is low Hb has low affinity (hard to get) oxygen. It will release oxygen to the tissues
However there is steep increase in %saturation of O2 with haemoglobin with small increases in pO2 (middle section of graph) as after the first O2 molecule has bound to haemoglobin there is a change in its tertiary structure making it easier for subsequent O2 molecules to bing
when the percentage of oxygen is high Hb has a high affinity for the oxygen
It will join to oxygen and become more saturated
100% saturation means all Hb molecules are carrying the max of 4 oxygen molecules

40
Q

delete

A

delete

41
Q

how is oxygen concentration measured?

A

As partial pressure (pO2)

42
Q

what is fetal haemoglobin? how is it different to normal haemoglobin?

A

Fetus gets O2 from its mother’s blood across the placenta
Mothers placenta has a low partial pressure of O2

Fetal haemoglobin has a higher affinity for oxygen at all partial pressures of O2
This means its oxygen dissociation curve is positioned to the left of adult hemoglobins one (same shape)

The difference in affinites is essential to the survival of the fetus as it means that oxygen will unload from oxyhaemoglobin at the placenta and bind to fetal haemoglobin; supplying the fetus with oxygen.

43
Q

what is the Bohr effect?

A

In areas where theres is a high pCO2 the oxygen dissociation curve moves to the right signifying that there is a lower affinity of haemoglobin for oxygen in these conditions. This is known as the BOHR shift

At high pCO2 (e.g respiring tissues) haemoglobin has a low affinity for oxygen and a high affinity for CO2.

This is useful as it means that oxygen will unload from haemoglobin and CO2 will bind to haemoglobin/ diffuse into RBC instead.

This allows respring tissues to be supplied with O2 and CO2 to be taken away from them rapidly

44
Q

what are the three ways carbon dioxide is transported around the body?

A

5% Dissolved in blood plasma
10-20% Carbaminohaemoglobin
75-85% Transported in the form of hydrogencarbonate ions

45
Q

how do hydrogen carbonate ions form

A

As CO2 diffuses into the blood, some of it enters the RBC’s.
It combines with water to form a weak acid = carbonic acid
This is catalysed by carbonic anhydrase (an enzyme)

CO2 + H2O → H2CO3

This carbonic acid dissociates to release hydrogen ions (H+) and hydrogen carbonate ions (HCO3-)

The hydrogencarbonate ions diffuse out of the RBC’s into the plasma.

46
Q

what is chloride shift

A

The negatively charged hydrogen carbonate ions move out of the erythrocytes into the plasma by diffusion down a concentration gradient.

Negatively charged chloride ions move into the erythrocytes which maintains an electrolyte balance of the cell

47
Q

how does haemoglobin act as a buffer

A

it acts as a buffer and prevents changes in the pH by accepting free hydrogen ions in a reversible reaction to form haemoglobinic acid

48
Q

what happens when blood reaches the lung tissue

A

there is a relatively low co2 concentration
carbonic anhydrase catalyses the reverse reaction - breaking down carbonic acid into co2 and water
hydrogen carbonate ions diffuse back into the red blood cells and react with hydrogen ions to form more carbonic acid. this releases free carbon dioxide which diffuses from the blood to the lungs.
chloride ions diffuse out of the red blood cells back into the plasma down an electrochemical gradient.

49
Q

what is the mammalian heart made of and how does it move

A

cardiac muscle

contracts and relaxes in a regular rhythm

50
Q

delete

A

delete

51
Q

what are all the features in the heart

A 
aorta
pulmonary vein
left atrium
heart valve
left ventricle
septum
right ventricle
right atrium
vena cava
pulmonary artery
52
Q

what is the order of blood flow in the body

A 
left ventricle
aorta
body
vena cava
right atrium
right ventricle
pulmonary artery
lungs
pulmonary vein
left atrium
left ventricle
53
Q

what is the septum

A

where the two sides of the heart are divided by a layer of muscle

54
Q

what is the right atrium and the left atrium

A

the two small chambers at the top of the heart

55
Q

what is the right ventricle and the left ventricle

A

two larger chambers at the bottom of the heart

56
Q

what are the pulmonary veins

A

blood vessels that bring oxygenated blood from the lungs into the left atrium

57
Q

what is the aorta

A

very large blood vessel that carries oxygenated blood from the left ventricle to the rest of the body

58
Q

what is the pulmonary artery

A

blood vessel that takes deoxygenated blood from the right ventricle and delivers it to the lungs

59
Q

what is the vena cava

A

blood vessel that brings deoxygenated blood from the body and empties it into the right atrium

60
Q

what is diastole

A

the whole heart is relaxed and the atria fill with blood

61
Q

what is atrial systole

A

the atria contract squeezing blood into the ventricles

62
Q

what is the ventricular systole

A

the ventricles contract squeezing blood out of the heart

63
Q

what is the first main stage of a heartbeat

A

Ventricles relaxed
The atria contract, which decreases their volume and increases their pressure
This pushes blood into ventricles through AV valves
There’s a slight increase in ventricular pressure and volume as the ventricles receive blood from atria

64
Q

what is the second main stage of a heartbeat

A

Atria relax
Ventricles contract (decreasing their volume), increasing pressure
Pressure becomes higher in ventricles than atria, causes AV valves to shut preventing backflow
High pressure in ventricles opens semi-lunar valves
Blood is forces into the pulmonary artery and aorta

65
Q

what is the third main stage of a heartbeat

A

Ventricles and atria both relaxed
Higher pressure in pulmonary artery and aorta causes semi-lunar valves to close, preventing backflow
Atria fill with blood (increasing their pressure), due to higher pressure in vena cava and pulmonary vein
Ventricles continue to relax, pressure falls below the pressure in the atria, causing AV valves to open and blood flows passively (70%) into ventricles from atria
The atria contracts, cycle starts again

66
Q

when will the tricuspid and bicuspid valves open and why

A

During atrial systole. The atrial contraction causes the blood pressure to be higher in the atria than the ventricles forcing them open

67
Q

when will the semilunar valves open and why

A

When the pressure in the ventricles is higher than the aorta/pulmonary artery, so that the blood is forced out into the arteries

68
Q

delete

A

delete

69
Q

what causes the sounds in the heart

A

the sounds are from the blood pressure closing the heart valves.
They are described as lub-dub.
The 1st sound comes from the blood forced against the AV valves as the ventricles contract.
The 2nd sound comes as a backflow of blood closes the semi lunar valves in the aorta and pulmonary artery as the ventricles relax.

70
Q

What does it mean when you say the cardiac muscles is myogenic?

A

it doesn’t need to be told to beat

sets its own rhythm

71
Q

what is the order of the wave of excitation?

A
  • SAN (sinoatrial node) is located in the right atrium - it starts the wave of excitation
  • The wave passes over the walls of the atria causing it to contract
  • Non-conductive tissue prevents the wave from passing straight down to the ventricles.
  • The wave is picked up by the AVN (atrioventricular node)
  • This delays the wave slightly before passing it down the bundle of His in the septum.
  • Bundle of His splits up both sides of the ventricles and passes the wave from the apex up the sides of the ventricles.
  • This causes the ventricles to contract from apex to top.
72
Q

why is the bundle of His important in a heartbeat

A

It splits into 2 branches and conducts the wave of excitation to the apex.
The purkyne fibres spread out through the wall of the ventricles.
This triggers contraction of ventricles starting at the apex.
Contraction starting at the apex allows more efficient emptying of the ventricles.

73
Q

what is an ECG?

What are the stages?

A 
Electrocardiograms
measures electrical activity of the heart
1) contraction of atria
2) (the point) contraction of ventricles
3) relaxation of ventricles
74
Q

what is tachycardia?

A

a fast resting (above 100bpm) heartbeat caused for no reason
the heart produces rapid electrical signals
pumps less efficiently so blood flow is reduced
the muscles are using more oxygen because they are pumping quicker so if it carries on then you could have a cardiac arrest because the muscles aren’t receiving enough oxygen
treatment includes relaxation therapy or beta blocker

75
Q

what is an increased heartbeat due to?

A

excitement
stress
exercise
drugs

76
Q

delete

A

delete

77
Q

delete

A

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78
Q

what is bradycardia

A

when the heart rate slows down below 60bpm

79
Q

what is an ectopic heartbeat

A

extra heartbeats that are out of normal rhythm

happens to everyone once a day but if it regular then it can be dangerous

80
Q

What happens to the pressure of the left atria in a heartbeat

A
  • The pressure is lower than ventricles and aorta as thin walls so doesn’t give much force
  • when contracting the atria is at its highest pressure as there’s a lot of blood
  • pressure then drops as no blood in atria and AV valve is closed so now in relax phase
  • pressure increases again as atria fills with blood
81
Q

What happens to the pressure of the left ventricle through a heartbeat

A
  • When ventricles are relaxing, pressure is low
  • when AV valves close, all blood in ventricles so pressure goes up as ventricles contract
  • when pressure of ventricles goes above the aortic pressure, that’s when the SL valves open and blood goes into the aorta
  • then pressure goes down as the blood leaving the ventricles and relaxing again
82
Q

What happens to the aortic pressure in a heartbeat

A

Pressure rises when ventricles contract as blood is going into the aorta
Pressure falls once all the blood has gone through
Semilunar valve closing and recoiling phase produces a temporary pressure rise

83
Q

Describe and explain how the structure of the artery is adapted to allow it withstand and maintain a high blood pressure [4]

A

Withstand:
Thick outer layer of collagen provide strength
Folded endothelium prevents damage to the artery walls e.g. tears as it will stretch

Maintain:
Elastic fibers allow the artery to stretch and recoil
Thick layer of smooth muscle constricts which narrows the lumen of the artery.

ABHAYS A-LEVEL BIO FLASHCARDS (24 decks)

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