m2-4 quiz Flashcards
Ownership of intellectual property in academic research in Germany and the US is held by
(more than one answer is correct)
A. the inventor(s)
B. the funding agency
C. the University
D. Researcher(s) who are not employed by the University but inventor(s)
C. the University
D. Researcher(s) who are not employed by the University but inventor(s)
Which cognitive functions are typically impaired in patients with lesions of the lateral prefrontal cortex?
A. Patients typically show impaired social behavior, poor judgments and impaired decision making.
B. Patients typically show impaired long-term memory functions.
C. Patients typically show impaired language comprehension.
D. Patients are typically impaired in planning, abstract reasoning and maintenance of task-relevant information.
E. Patients typically have lost the ability to accurately attribute mental states to other people.
D. Patients are typically impaired in planning, abstract reasoning and maintenance of task-relevant information.
Which statement is not correct?
- Microangiopathy
- Headache
- Cardioembolism
- Hemiparesis
- Artherothrombosis
- Headache
The dopaminergic input-neurons of monkeys (mediated by midbrain structures)
contacting prefontal cortex …
A. are unable to adapt to changes in context-conditions.
B. don’t fire if there is an unexpected reward.
C. can be conditioned with a neutral stimulus, so that the neutral stimulus alone leads to firing of the dopaminergic neurons.
D. show increased activity by withdrawing an earlier given reward.
E. are heavily interconnected with the cerebellum.
C. can be conditioned with a neutral stimulus, so that the neutral stimulus alone leads to firing of the dopaminergic neurons.
What has the neurotransmitter dopamine been shown to encode?
A. stop signals
B. reward signals
C. fear signals
D. motor signals
B. reward signals
Depression
A. is associated with increased amygdala responses to negative emotional stimuli.
B. is caused by reduced activity of the nucleus accumbens.
C. is related to an overactivation of the pineal gland.
D. is known to be associated with increased activity of the posterior cingulate cortex.
E. is related to decreased hippocampus activity during REM sleep.
A. is associated with increased amygdala responses to negative emotional stimuli.
The cerebellum comprises of
- A cerebellar cortex, white matter, deep cerebellar and nuclei and some parts of the vestibular nuclei
- A cerebellar cortex with the molecular, Purkinje cell and granular layer
- Only the lobuli centralis, semilunaris inferior and superior
- The cerebellar cortex and the DCN (dorsal cochlear nuclei)
- A cerebellar cortex, white matter and deep cerebellar nuclei
- A cerebellar cortex, white matter, deep cerebellar and nuclei and some parts of the vestibular nuclei
Which of these anatomic structures is not part of the basal ganglia?
A. Striatum
B. Pontine nucleus
C. Subthalamic nucleus
D. Globus pallidus internus
B. Pontine nucleus
If you are interested to study cerebellar functions, which of the following disorders are not good human lesion models?
A) Stroke within the territory of the superior cerebellar artery
B) Spinocerebellar ataxia type 3 (SCA 3)
C) Surgical removal of cerebellar astrocytoma
D) Spinocerebellar ataxia type 6 (SCA 6)
E) Friedreich’s ataxia
1. B and E 2. E 3. A, B and E 4. A, B, C and D 5. A and E
- B and E
B) Spinocerebellar ataxia type 3 (SCA 3)
E) Friedreich’s ataxia
The lifetime prevalence of anxiety disorders is about:
A. 70% B. 5% C. 1% D. 20% E. 50%
D. 20%
The frontal lobe
A. Spans 1/8 of the total cortex in humans
B. Is separated to the temporal lobe by the postcentral sulcus
C. Is subdivided into primary motor cortex, the premotor cortex and the prefrontal cortex
D. Is separated to the parietal lobe by the precentral sulcus
E. Greatly enlarged in the course of evolution in parallel to the development of motor abilities
C. Is subdivided into primary motor cortex, the premotor cortex and the prefrontal cortex
One of the following statements is WRONG – Which one?
Alexia without agraphia is disconnection syndrom typpically with the following characteristricts
- language difficulties
- a lesion in the splenium
- patients can´t read but write
- a left hemispheric lesion
- a visual field defect
- language difficulties
Which medications are approved for the prophylaxis of bipolar disorder? A Lithium B Benzodiazepines C Valproic acid D Serotonin-Reuptake Inhibitors E Hypnotics
- only B is correct
- A and C are correct
- All are correct
- B and D are correct
- A, C and E are correct
- A and C are correct
A Lithium
C Valproic acid
Which of the following statements are correct?
(more than one answer is correct)
The executive system….
A. is concerned with the co-ordination of other cognitive resources
B. is needed when automatic psychological processes would not be sufficient, in cases of novel situations
C. is a brain function charged with implementing, or executing, the law
D. damage to the system can have a wide range of effects in different domains, for example in
social interaction, executive memory and abstract thinking
E. specifically describes the execution of motor commands
A. is concerned with the co-ordination of other cognitive resources
B. is needed when automatic psychological processes would not be sufficient, in cases of novel situations
D. damage to the system can have a wide range of effects in different domains, for example in
social interaction, executive memory and abstract thinking
The prevalence rate of panic disorder is:
- 10-15%
- 20-30%
- 1%
- 3-5%
- 0.2-0.5%
- 3-5%
Which answer is incorrect?
A. Abnormal dopamine, glutamate, and GABAergic signaling are all hypothesized to contribute to schizophrenia.
B. Variation in immune related genes are strongly associated with schizophrenia.
C. Schizophrenia only effects a small proportion of the population.
D. Schizophrenia is a disorder of the brain.
E. Clinical presentation of schizophrenia is heterogeneous.
C. Schizophrenia only effects a small proportion of the population.
Which of these anatomic structures is not part of the basal ganglia?
A. Corpus striatum
B. Red nucleus
C. Subthalamic nucleus
D. Caudate nucleus
B. Red nucleus
The following statement is true in regard to the cerebellar cortex
- Only basket and stellate cells are inhibitory interneurons
- Granule cells excite other granule cells
- Purkinje cells inhibit granule cells
- The granular cells are the only excitatory interneurons
- Golgi cells are contracted by climbing fibers and Purkinje cells
- The granular cells are the only excitatory interneurons
Preclinical studies are often
A. over-powered B. of low internal validity C. predictive for clinical efficacy D. the basis for claiming intellectual property E. replicated
B. of low internal validity
Which of the following statements are RIGHT?
(more than one answer is correct)
The frontal lobe includes:
A. premotor area B. primary somatosensory cortex C. prefrontal cortex D. primary motor cortex E. precuneus
A. premotor area
C. prefrontal cortex
D. primary motor cortex
Which of the following statements is correct?
A. In patients, stroke causes subsequent chronic epilepsy in more than 50 % of patients.
B. In patients, epileptogenesis after brain injuries can take up to several years.
C. Status epilepticus rarely induces epileptogenesis in patients and rodents.
D. Epileptogenesis can be prevented by pharmacological and non-pharmacological treatment approaches.
E. Primary prophylaxis (i.e. treatment before occurrence of the first seizure) is commonly advised in patients with brain tumors.
B. In patients, epileptogenesis after brain injuries can take up to several years.
One of the following statements is WRONG – Which one?
“Disconnection syndromes”
- means that two cortical areas are linked together irregularly ( = dysconnection) by aberrant fiber tracts
- may result from transection of the corpus callosum (so-called “split-brain” operations)
- are functional deficits caused by focal lesions of fiber tracts that connect cortical brain areas
- may refer to interruption of intrahemispheric as well as interhemispheric fiber tracts
- are characterized by anatomical lesion sites (and therefore disconnection symptoms might refer to different cognitive or neuronal systems)
- means that two cortical areas are linked together irregularly ( = dysconnection) by aberrant fiber tracts
Which symptoms can be associated with a depressive episode?
1) Insomnia
2) Disinhibition
3) Weight loss
4) Anhedonia
5) Psychomotor retardation
- 3 and 4 are correct
- 2, 3, 4, are correct
- All are correct
- 1, 3, 4 and 5 are correct
- 1 and 2 are correct
- 1, 3, 4 and 5 are correct
Antidepressants …
- should not be taken continuously
- have the risk of dependency
- need 2-4 weeks to get effective
- change the character
- must not be taken by people driving cars
- need 2-4 weeks to get effective
Which of the five clinical signs is not a typical cerebellar sign?
A. Dysmetria B. Intention tremor C. Akinesia D. Dysarthria E. Asynergia
C. Akinesia
What are types of bias affecting the “internal validity” of a study?
A. selection bias (creating groups with different confounders; solved by randomization)
B. performance bias and detection bias (investigators respectively treating or assessing more positively those subjects on the treatment arm; controlled by blinding interventions and outcome assessments);
C. attrition bias (dropouts of subjects with a negative outcome not included in the final result)
D. all of the above
D. all of the above
Manic-depressive mixed states are
- A combination of 2 depressive and 4 manic symptoms
- Characterized by fluctuations in mood symptoms of opposite polarity
- More frequent in men than in women
- More often associated with a good prognosis than pure episodes
- Easy to treat
- Characterized by fluctuations in mood symptoms of opposite polarity
Posttraumatic stress disorder is in most cases not associated with
A. Delusions B. Flashbacks C. Nightmares D. Hyperarousal E. Avoidance of stimuli associated with the trauma
A. Delusions