M-Ab and Ib Flashcards
1
Q
Pembrolizumab?
A
PD-1
2
Q
Nivolimumab?
A
PD-1
3
Q
Ipilimumab?
A
CTLA -4
4
Q
Debrafenib?
A
BRAF - all V600 mutations
Met melanoma
5
Q
Debrafenib side effects?
A
Photsensitive skin rash
SCC
Fever
Arthalgia
6
Q
Trametinib ?
A
MEK inhibitors
- Melanoma
7
Q
Use of Debrafenib and Trametinib?
A
Mestatic Melanoma - in BRAF +ve patient
Use both BRAF and MEK inhibitors
8
Q
Sunitinib and Sorafenib ?
A
Multi- target TKI
9
Q
Sunitinib and Sorafenib AE?
A
Hypertension - indicates response!
Hand - foot skin reaction
10
Q
Use of Sunitinib ?
A
RCC
11
Q
Erlotinib side effect?
A
Acne rash - indicates response
12
Q
Erlotinib ?
A
eGFR TKI lung
13
Q
Gefitinib ?
A
eGFR TKI lung
14
Q
Cetuximab ?
A
mAb to eGFR
- use in CR, and H and N
15
Q
Imantinib?
A
BCR-ABL TKI and c-kit (also used in CML and GIST )
