M-Ab and Ib

Question 1

Pembrolizumab?

Answer 1

PD-1

Question 2

Nivolimumab?

Answer 2

PD-1

Question 3

Ipilimumab?

Answer 3

CTLA -4

Question 4

Debrafenib?

Answer 4

BRAF - all V600 mutations

Met melanoma

Question 5

Debrafenib side effects?

Answer 5

Photsensitive skin rash
SCC
Fever
Arthalgia

Question 6

Trametinib ?

Answer 6

MEK inhibitors

- Melanoma

Question 7

Use of Debrafenib and Trametinib?

Answer 7

Mestatic Melanoma - in BRAF +ve patient

Use both BRAF and MEK inhibitors

Question 8

Sunitinib and Sorafenib ?

Answer 8

Multi- target TKI

Question 9

Sunitinib and Sorafenib AE?

Answer 9

Hypertension - indicates response!

Hand - foot skin reaction

Question 10

Use of Sunitinib ?

Answer 10

RCC

Question 11

Erlotinib side effect?

Answer 11

Acne rash - indicates response

Question 12

Erlotinib ?

Answer 12

eGFR TKI lung

Question 13

Gefitinib ?

Answer 13

eGFR TKI lung

Question 14

Cetuximab ?

Answer 14

mAb to eGFR

- use in CR, and H and N

Question 15

Imantinib?

Answer 15

BCR-ABL TKI and c-kit (also used in CML and GIST )

Question 16

Bevacizumab ?

Answer 16

VGEF

- use in K-RAS mutant CRC

Question 17

Crizotonib?

Answer 17

ALK ( also use if ROS -1 positive)

- use in NSCLC

Question 18

Belimumab?

Answer 18

is a mAB against soluble BAFF( potenitates naive B cells) Used in SLE