Other drugs Flashcards
1
Q
How does imetelstat work ?
A
- Anti-sense therapy is when a genetic sequence is known to cause a particular disease, then a strand of DNA/RNA can be synthesised that will bind to mRNA produced by the genes and inactivate it.
- Anti-sense oligonucleotides are small RNA/DNA molecules that are used for this purpose.
- E.g.Imetelstat
- Imetelstat is an antisense oligonucleotide that inhibits telomerase activity, and impede cell growth. It is in phase 2 trials for myeloproliferative neoplasms – myelofibrosis and ET
2
Q
How does sacubril work?
A
- Sacubril is an neprilysin inhibitor
- Neprilysin is responsible for degradation of ANP and BNP, which cause reduction in blood volume through decrease in systemic vascular resistance and increase in natriuresis, and thus decrease in afterload.
3
Q
What are the benefits of sacubril/valsartan?
A
• Reduction in CVD death, heart failure hospitalistaions, death from any cause by 20% compared to ACE alone
4
Q
How does riociguat work ?
A
In PAH there is dysfunction of the NO-soluble guanylate cyclase monophosphate pathway. Riocigiuat is an sGC stimulator causing vasodilation,
