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Hematology II > Lymphomas and Plasma cell disorders > Flashcards

Lymphomas and Plasma cell disorders Flashcards

1
Q

Focus on B-cell proliferation

A

Lymph node Cortex

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2
Q

B lymphs and plasma cells

A

Lymph node Medulla

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3
Q

Contains T cells and macrophages

A

Lymph node paracortex

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4
Q

CD19, CD20, CD5

A

Naive B lymph CD markers

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5
Q

CD3, CD5, CD2, CD7, CD4, and CD8

A

T cell CD markers

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6
Q
  • Formation of new B lymphocytes
  • Processing of specific immunoglobulins
  • Filtration of matter, debris, and bacteria
A

Lymph node functions

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7
Q

In the pathology laboratory (moist)
- sliced into 3 mm-thick sections
-touch imprints
- thin sections

A

Lymph node processing

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8
Q

Morphology
Immunophenotype
Molecular Characteristics
Clinical Characteristics

A

Lymphoma subtypes are distinguished by…

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9
Q

Abnormal, destructive lymph node enlargement

A

Lymphoma characteristic

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10
Q

Progression into a leukemia

A

Peripheralization

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11
Q
  1. Mature B cell lymphoma
  2. Mature T cell lymphoma
A

Lymphoma categories

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12
Q

Reed sternberg cell

A

Hodgkin’s lymphoma

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13
Q

More common in kids

A

Hodgkin’s lymphoma

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14
Q

Happens to ALL ages

A

Non-Hodgkins Lymphoma

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15
Q

Unifocal origin with predictable spread along lymph node chain

A

Hodgkins

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16
Q

Presents with painless, englarged cervical lymph nodes

A

Hodgkins

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17
Q

Prognosis good if still localized (>90% cure)

A

Hodgkin’s lymphoma (HL)

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18
Q

Multifocal origin with unpredictable spread

A

Non-Hodgkins Lymphoma (NHL)

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19
Q

Malignant cell is B lymph in 95% of cases

A

Non-Hodgkins Lymphoma (NHL)

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20
Q

“owl-eyes”

A

Reed- Sternberg cell

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21
Q

Accurate staging crucial to treatment

A

Hodgkin’s lymphoma (HL)

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22
Q

Staging not as crucial

A

Non-Hodgkins Lymphoma (NHL)

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23
Q

Pleomorphic cells, some normal, some malignant

A

Hodgkin’s lymphoma (HL)

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24
Q

Uniform, malignant cells

A

Non-Hodgkins Lymphoma (NHL)

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25
Q

Presents with painless, enlarged cervical lymph nodes & at a more advanced stage

A

Non-Hodgkins Lymphoma (NHL)

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26
Q

Prognosis worse

A

Non-Hodgkins Lymphoma (NHL)

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27
Q

fever, weight loss, night sweats (poor prognostic indicator)

A

B-symptoms

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28
Q

Popcorn cells

A

Nodular lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)

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29
Q

Cells are positive for CD20 and CD45

A

Nodular lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)

30
Q

strong association w/ cmyc proto-oncogene rearrangement on chromosome 8

A

Non-Hodgkin’s Lymphoma (NHL)

31
Q

NHL typically_____ have a leukemic presentation at the end stage of the disease

A

does

32
Q

Essential to accurately stage disease to determine treatment and prognosis!

A

Diagnosis of HL

33
Q

Radiation and chemo. Can affect 90% cure rate if disease is localized!

A

Hodgkins treatment

34
Q

slow-growing

A

Low grade NHL

35
Q

extranodal disease

A

Intermediate grade NHL

36
Q

rapidly growing - rapidly fatal

A

High grade NHL

37
Q

ranks according to aggressivity: low, intermediate or high grade

A

NHL (1982)

38
Q

All produce monoclonal light chain immunoglobulin gene rearrangements, or both

A

Mature B cell lymphomas

39
Q

Derived from circulating IgM, IgD B-cells

A

Small Lymphocytic Lymphoma/CLL

40
Q

positive for CD19, CD20, and CD23 (+/- CD5)

A

Small Lymphocytic Lymphoma/CLL

41
Q

Linked to t(11;14) defect

A

Mantle Cell Lymphoma

42
Q

CD5, CD19, CD20; but negative for CD23!

A

Mantle Cell Lymphoma

43
Q

Linked to t(14:18) and (q32;q21)
- positive for CD19 and CD20

A

Follicular Lymphoma

44
Q
  • Diffuse proliferation of large lymphocytes (Twice the size of normal lymphs)
  • Most common lymphoma (30-40%)
A

Diffuse large B cell Lymphoma (DLBCL)

45
Q
  • “Starry sky”
  • CD10, CD19, and CD20
  • MYC gene
A

Burkitt Lymphoma

46
Q

Diagnosis is considered a medical emergency

A

Burkitt Lymphoma

47
Q

skin presentation stage of a T cell lymphoma

A

Mycosis Fungoides

48
Q

Typically see pruritus, followed by weepy erythroderma

A

Mycosis Fungoides

49
Q

Mycosis fungoides is THE most ____ cutaneous lymphoma

A

common

50
Q

P.B presentation stage of T cell lymphoma

A

Sezary syndrome

51
Q

Sezary syndrome has _____ prognosis

A

BAD

52
Q

“butt cells”

A

Sezary Syndrome (not specific for this)

53
Q

Topical chemo. & superficial radiation for _____ _______

A

mycosis fungoides

54
Q

HAART

A

Highly Active Antiretroviral Therapy

55
Q

increases CD4 counts, unfortunately does not ↓ rate of incidence of HIV-related lymphomas

A

HAART

56
Q
  • HIV infection increases general lymphoma risk (by ~ 60X)
  • Many types (NHL, HL, Burkitt’s, etc.) may occur, especially late in AIDS
  • Usually very aggressive
A

HIV-Related Lymphoma

57
Q

MM occurs when a tumor of ________ overgrows in the bone marrow

A

malignant plasma cells

58
Q

plasma cells that contain ____ ______(rounded accumulations of IG in rER), are called Mott cells/grape cells/morula cells

A

Russell bodies

59
Q

Plasma cell seen in IgA myeloma is called a ___ ___

A

flame cells

60
Q

_______(starch-like protein deposits) are deposited throughout body, causing multiple organ defects

A

Amyloid

61
Q

_____ – new drug; strengthens bones

A

Aredia

62
Q

Occurs when absolute # of circulating plasma cells exceeds cutoff (>2000/uL)

A

Plasma Cell Leukemia (PCL)

63
Q

proteasome inhibition causes more _______ in malignant cells than in normal cells!

A

apoptosis

64
Q

Malignant plasmacytoid lymphocytes

A

Waldenstrom’s Macroglobulinemia (WM)

65
Q
  • Oversecretion of IgM
  • Abnormally increased CD20 cell surface markers
A

Waldenstrom’s macroglobulinemia

66
Q

moderate rouleaux in p.b.

A

Multiple Myeloma

67
Q

Length of survival - WORSE

A

Multiple myeloma

68
Q

More common prevalence

A

Multiple Myeloma

69
Q

Rare hepatosplenomegaly

A

Multiple Myeloma

70
Q

Marked lytic bone lesions

A

Multiple Myeloma

71
Q

May occur as end-stage sequela of MM or by itself

A

Plasma Cell Leukemia

Hematology II (8 decks)

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