Lymphocytic Leukemias Flashcards
cCD22
Early cell marker
cCD22 positive in which Lymphocytic Leukemias
Early B-ALL
Intermediate (common) B-ALL
Pre-B-ALL
sCD22
surface CD22
sCD22 positive in what Lymphocytic leukemia
Mature B-ALL
CD10 known as?
CALLA
CD10 is positive for what Lymphocytic Leukemia
Common ALL
Most common B-cell ALL
CALLA
B-ALL t(9;22)
worst prognosis
B-ALL t(12;21)
Excellent prognosis in children
Hyperdiploidy
good prognosis
Hypodiploidy
bad prognosis
- Poor prognosis
- Seen in adult & late teen males
- mediastinal mass in teenage boys
- Positive for ACP
T-cell ALL
rare ALL
T-cell ALL
3 Chronic lymphoproliferative leukemias
- Chronic Lymphocytic Leukemia
- Polymorphocytic Leukemia
- Hairy cell leukemia
Most common leukemia occuring in ELDERLY patients (men)
CLL/SLL
Many smudge cells in peripheral blood due to marked cytoplasmic fragility (also seen in ALLs)
CLL/SLL
Report smudge cells as number per ____ WBCs diffed
100
Bone marrow PAS + → for what substance
Glycogen
Most Common Leukemia/lymphoma in Western Hemisphere
Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)
Mature-looking, but functionally immature, B cells
Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)
CD19, CD20, CD23,
CLL/SLL
Diagnosis based on Monoclonal B-lymphs > 5,000/uL
CLL/SLL
Appear “hypermature” → some have “soccer ball” appearance ⚽
CLL/SLL
Diagnosis requires >55% prolymphocytes
PLL
Punched out nucleolus is characteristic finding
PLL
CD20, CD19, CD22, and FMC7
PLL
More common in middle-aged men
HCL
Characteristic pancytopenia & “dry tap” on bone marrow aspiration
HCL
CD19, CD20, CD22, CD25, and CD103
HCL
Hugely enlarged spleen → in 90% of the patients
HCL
PAS, SBB, and MPO → negative
Hairy Cell Leukemia
