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Hematology II > Lymphocytic Leukemias > Flashcards

Lymphocytic Leukemias Flashcards

1
Q

cCD22

A

Early cell marker

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2
Q

cCD22 positive in which Lymphocytic Leukemias

A

Early B-ALL
Intermediate (common) B-ALL
Pre-B-ALL

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3
Q

sCD22

A

surface CD22

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4
Q

sCD22 positive in what Lymphocytic leukemia

A

Mature B-ALL

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5
Q

CD10 known as?

A

CALLA

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6
Q

CD10 is positive for what Lymphocytic Leukemia

A

Common ALL

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7
Q

Most common B-cell ALL

A

CALLA

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8
Q

B-ALL t(9;22)

A

worst prognosis

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9
Q

B-ALL t(12;21)

A

Excellent prognosis in children

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10
Q

Hyperdiploidy

A

good prognosis

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11
Q

Hypodiploidy

A

bad prognosis

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12
Q
  • Poor prognosis
  • Seen in adult & late teen males
  • mediastinal mass in teenage boys
  • Positive for ACP
A

T-cell ALL

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13
Q

rare ALL

A

T-cell ALL

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14
Q

3 Chronic lymphoproliferative leukemias

A
  1. Chronic Lymphocytic Leukemia
  2. Polymorphocytic Leukemia
  3. Hairy cell leukemia
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15
Q

Most common leukemia occuring in ELDERLY patients (men)

A

CLL/SLL

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16
Q

Many smudge cells in peripheral blood due to marked cytoplasmic fragility (also seen in ALLs)

A

CLL/SLL

17
Q

Report smudge cells as number per ____ WBCs diffed

A

100

18
Q

Bone marrow PAS + → for what substance

A

Glycogen

19
Q

Most Common Leukemia/lymphoma in Western Hemisphere

A

Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

20
Q

Mature-looking, but functionally immature, B cells

A

Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)

21
Q

CD19, CD20, CD23,

A

CLL/SLL

22
Q

Diagnosis based on Monoclonal B-lymphs > 5,000/uL

A

CLL/SLL

23
Q

Appear “hypermature” → some have “soccer ball” appearance ⚽

A

CLL/SLL

24
Q

Diagnosis requires >55% prolymphocytes

A

PLL

25
Q

Punched out nucleolus is characteristic finding

A

PLL

26
Q

CD20, CD19, CD22, and FMC7

A

PLL

27
Q

More common in middle-aged men

A

HCL

28
Q

Characteristic pancytopenia & “dry tap” on bone marrow aspiration

A

HCL

29
Q

CD19, CD20, CD22, CD25, and CD103

A

HCL

30
Q

Hugely enlarged spleen → in 90% of the patients

A

HCL

31
Q

PAS, SBB, and MPO → negative

A

Hairy Cell Leukemia

Hematology II (8 decks)

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