Lymphomas Flashcards
True or false. The incidence of NHL is nearly 10x the incidence of Hodgkins Lymphoma.
True
True or false. Patients with both primary and secondary immunodeficiency states are predisposed to developing non-NHL.
True
____ is stronly associated with the occurence of extranodal nasal NK/Tcell lymphomas in Asia and South America.
EBV infection
This infectious agent is associated with gastric MALT lymphoma.
Helicobacter pylori
This infectious agent is associated with primary effision lymphoma and Multicentric Castleman’s disease.
Human herpesvirus 8
HIV is associated with these lymphoid malignancies.
- Diffuse large B-cell lymphoma
- Burkitt’s Lymphoma
True or false. About 90% of all lymphomas are of B-cell origin.
True
These are important independent prognostic factors in NHL.
- Serum B-2 microglobulin level
2. Serum LDH
True or false.
Since HIV and Hepatitis B and C infection can be risk factors for developing NHL, and since treatment for some NHL can result in the potentially life threatening reactivation of Hepatitis B, patients with newly diagnosed NHL should be screened for these viruses as well.
True
This is useful to detect aggressiveness of lymphomas.
FDG PET.
The intensity of FDG avidity, or SUV, correlates with histologic aggressiveness.
PET should only be used for DLBCL and Hodgkins lymphoma, that scanning during therapy should only be done as part of clinical trials, and that end-of-treatment scan should not be done before ___ weeks, but preferably ___ weeks after chemotherapy and ___ weeks after radiation or chemoradiatiotherapy.
should not be done before 3weeks, but preferably 6-8weeks after chemotherapy and 8-12 weeks after radiation or chemoradiatiotherapy
What is the Ann Arbor Stage?
Involvement of a single LN or single extranodal site.
I
What is the Ann Arbor Stage?
Involvement of two or more LN regions or lymphatic structures on the SAME SIDE OF THE DIAPHRAGM alone or with involvement of limited, contiguous, extralymphatic organ or tissue.
II
What is the Ann Arbor Stage?
Involvement of LN regions on BOTH SIDES OF THE DIAPHRAGM, which may include spleen, or limited, contiguous, extralymphatic organ or tissue, or both.
III
What is the Ann Arbor Stage?
Diffuse or disseminated foci of involvement of one or more extralymphatic organs or tissues, with or without associated lymphatic involvement.
IV
What are the five clinical risk factors included in the International Prognostic Index for NHL?
- Age >60 years
- Serum LDH elevated
- ECOG >=2 or Karnofsky <=70
- Ann Arbor Stage III or IV
- > 1 site of extranodal involvement
These are malignanct cells in HL.
Reed Sternberg Cells
This is one of the fastest growing neoplasms, with a doubling time of <24 hours. It has male preponderance, often <35 years old.
Burkitts Lymphoma
This form of Burkitts Lymphoma presents as a jaw or facial bone tumor that spreads to extranodal sites, usually EBV positive.
Endemic (African) form
This form of Burkitts Lymphoma usuallt has abdominal presentation with massive ascites and renal and testis/ovarian involvement, and also spreads to bone marrow and CNS, usually EBV negative.
Non-endemic form
True or false. Burkitts Lymphoma is chemosensitive.
True. All regimens incorprate high doses of cyclophosphamide.
This is the most common histologic subtype of NHL; with median age of 64 years.
Diffuse large B-cell lymphoma
Composition of R-CHOP
Rituximab+ cyclophosphamide, doxorubicin, vincristine, prednisone
This is the 2nd leading NHL; most common presentation is new, painless lymphadenopathy of multiple sites; elevated LDH and B symptoms are UNCOMMON
Follicular lymphoma
This NHL is associated with monoclonal IgM paraprotein. Patients with high levels of circulating IgM paraproteins constitute a specific entity known as ___, which have symptoms of hyperviscosity.
Lymphoplasmacytic Lymphoma NHL is associated with monoclonal IgM paraprotein. Patients with high levels of circulating IgM paraproteins constitute a specific entity known as Waldenstrom Macroglobulinemia, which have symptoms of hyperviscosity.
This is also known as cutaenous T-cell lymphoma.mit presents with several years lf eczematous or dermatitic skin lesions. Patients may develop generalized erythroderma and circulating tumor cells, called Sezary Syndrome.
Mycosis Fungoides
This NHL is a neoplasm driven by HTLV1, often contracted through breast milk of infected mothers. Aferage age at diagnosis is 60 years, with long latency.
Acute T-Cell Leukemia/Lymphoma
True or false. Hodgkin Lymphomas present with B symptoms and palpable nontender lymphadenopathy- neck, supraclavicular, axilla; more than half will have mediastinal adenopathy.
True
This is fever pattern that persists for days to weeks, followed by afebrile intervals and recurrence of the fever.
Pel Ebstein Fever
