Iron Deficiency Anemia Flashcards
Three stages of iron deficiency
- Negative iron balance
- Iron-deficient erythropoiesis
- Iron-deficiency anemia
Marrow stores are absent when serum ferritin level is ______
<15ug/L
Stage where microcytic cells first appear
Iron-deficient erythropoiesis
Formula for transferrin saturation
(Serum iron x 100) / TIBC
Signs of advanced tissue iron deficiency
Cheilosis
Koilonychia
Most convenient lab test to estimateiron stores
Serum ferritin
Normal/high serum iron, Tsat
Normal TIBC
Normal RDW
Smear: micro/hypo with targeting
Thalassemia
Low serum iron High TIBC Low Tsat Low ferritin High RDW
IDA
Normal micro/hypo Low serum iron Low TIBC Tsat low Ferritin normal/high
Anemia of inflammation/ chronic disease
Serum iron normal to high
TIBC normal
TSAT normal to high
Ferritin normal
Sideroblastic anemia (myelodysplastic anemia)
Amount of iron needed by an individual
Body weight (in kg) x 2.3 x (15-patient’s hgb, g/dL) +500 or 1000mg (for stores)
Which oral iron prep (tablet) has the greatest iron content? Arrange from least to greatest Ferrous sulfate 325mg Ferrous sulfate 195mg Ferrous sulfate extended release 525mg Ferrous fumarate 325mg Ferrous fumarate 195mg Ferrous gluconate 325mg Polysaccharide iron 150mg Polysaccharide iron 50mg
1. Ferrous gluconate 325mg (39) FeSO4 195mg (39) 2. Polysaccharide iron 50mg(50) 3. Ferrous fumarate 195mg (64) 4. FeSO4 325mg (65) 5. Extended release 525mg (105) 6. Ferrous fumarate 325mg (107) 7. Polysaccharide iron 150mg (150)