Acute Lymphoid Leukemia Flashcards
True or false. ALL is the most frequent neoplastic disease in children with an early peak at the age of 3-4 years.
True
True or false. There is a twentyfold increased incidence of leukemia in patients with Down syndrome, in whom ALL is increased in childhood or AML at an older age.
True
True or false. The WBC count in about 40% of ALL patients is reduced or normal.
True
Lumbar puncture in ALL is restricted to:
A. Patients with adequate platelet (>20x 10^9/L)
B. Absence of manifest clinical hemorrhage
C. Without a high WBC count
D. For safety reasons, all patients should receive intrathecal methotrexate at the first lumbar puncture
All are true
It is the detection of residual leukemic cells, not recognizable by light microscopy.
Minimal residual disease (MRD)
It is defined as leukemic cells not detectable by light microscopy (<5% blast cells in bone marrow).
Complete (hematologic) remission
It is defined as patient in complete remission, MRD not detectable, <0.01% = <=1 leukemic blast cell in 10,000
Complete molecular remission MRD-negativity
It is defined as patient in complete hematologic remission, but not in molecular complete remission >0.01%
Molecular failure / MRD- positivity
It is defined as >5% ALL cells in bone marrow/blood.
Hematologic relapse
These consists the maintenance therapy of ALL.
6-mercaptopurine and methotrexate
30% of adults with ALL develop CNS leukemia. Prophylactic CNS therapy in ALL is essential because of:
A. CNS leukemia is more easily prevented than treated
B. Once CNS leukemia has developed, it is generally followed by systemic relapse shortly after
C. Effective CNS prophylaxis also prevents systemic relapse
All are true
These are the surface antigen for B-cell lineage.
CD20, CD22, CD19
This anti-CD20 monoclonal antibody has substantially improved the outcome of patients with de novo Burkitts Lymphoma.
Rituximab
