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_Haematology > Lymphoma (Hodgkin + non-Hodgkin) > Flashcards

Lymphoma (Hodgkin + non-Hodgkin) Flashcards

1
Q

What cells does lymphoma affect?

A

lymphocytes

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2
Q

What percentage of lymphomas are non-Hodgkins?

A
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3
Q

What percentage of lymphomas are Hodgkins?

A
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4
Q

Give four risk factors for Hodgkins lymphoma

A
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5
Q

Exposure to pesticides and certain industrial chemicals is a risk factor for which type of lymphoma?

A
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6
Q

Helicobacter pylori and hep B + C are rick factors for which type of lymphoma?

A
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7
Q

What cells are affected in Hodgkin’s lymphoma?

A
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8
Q

What do B-cells mutate into in Hodgkin’s lymphoma?

A
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9
Q

What’s the main distinguishing feature between HL and NHL?

A

HL has presence of Reed-Sternberg cells

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10
Q

what are the two types of HL and how often are they both seen?

A

classical - presence of both RS cells and Hodgkin cells
nodular lymphocyte predominant - have lymphocyte-predominant cells (a variant of RS cells)

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11
Q

What are the four subtypes of classical HL?

A
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12
Q

What’s the most common symptom of HL?

A

painless, rubbery, enlarged lymph nodes

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13
Q

What are the B-symptoms associated with lymphoma?

A

fever
night sweats
weight loss > 10%

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14
Q

what two antigens are almost always expressed on RS cells in HL?

A

CD15 and CD30

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15
Q

What staging is used in HL?

A

Ann-arbor staging

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16
Q

What’s stage 1 in Ann-Arbor staging of HL?

A
17
Q

What’s stage 2 in Ann-Arbor staging of HL?

A
18
Q

What’s stage 3 in Ann-Arbor staging of HL?

A
19
Q

What’s stage 4 in Ann-Arbor staging of HL?

A
20
Q

What does the A suffix mean in Ann-Arbor staging of HL?

A
21
Q

What does the B suffix mean in Ann-Arbor staging of HL?

A
22
Q

What does the X suffix mean in Ann-Arbor staging of HL?

A
23
Q

Give the name of the staging used in Hodgkin’s lymphoma and describe a patient who is diagnosed
with StageIIIB (4 marks)

A
  • Ann Arbor Staging (1)
  • Multiple lymph nodes affected (1)
  • Above and below the diaphragm (1)
  • Presence of B symptoms (1)
24
Q
A

a.)
FBC - anaemia + high ESR (2)
CXR - wide mediastinum
blood film - Reed-Sternberg cells

b.)
HL

c.)
ABVD (chemotherapy combination)
bone marrow transplant (enables a higher dose of chemotherapy to be given)

NOTE: bone marrow transplant = stem cell transplant

25
Q
A
26
Q
A
27
Q
A
28
Q

What’s used for diagnosis of HL?

A

Lymph node biopsy

29
Q

What test is used to stage HL?

A

PET-CT

30
Q

What’s the 10 year survival rate for HL?

A

75%

31
Q
A
32
Q

In NHL, which cells are affected in what proportions?

A
33
Q

What are the two types of non-Hodgkin lymphoma depending on how quickly they grow?

A
34
Q

What’s the most common type of low grade NHL?

A

follicular lymphoma

35
Q

What are the three most common types of high grade NHL?

A
  • diffuse large B cell lymphoma (DLBCL)
  • Burkitt lymphoma
  • peripheral T cell lymphoma

_Haematology (14 decks)

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