Lymphoma basics

Question 1

Reactive follicular hyperplasia

Answer 1

BCL2 - in germinal centres
CD10, BCL6 + germinal centres
Ki67 very high, polarised
Polarised follicles with distinct marginal zones
Tingible body macrophages

Question 2

Follicular lymphoma

Answer 2

BCL2 + in germinal centres
CD10, BCL6 +
CD5, CycD1 -
CD23 = follicular dendritic cells only

Question 3

Small low grade B cell lymphoma panel

Answer 3

CD20
CD3
CD5
CD10
Bcl-2
Bcl-6
CycD1
CD23
Ki67

Question 4

CLL/SLL

Answer 4

CD10/BCL6 -
BCL-2, CD5, CD23 +
Proliferation centres

Question 5

MCL

Answer 5

CD10, BCL-6, CD23 -
BCL-2, CD5 +
Cyclin-D1 + (not specific!) 
Monotonous - no large neoplasm lymphocytes
?? other marker

Question 6

Marginal Zone lymphoma

Answer 6

No specific marker, diagnosis of exclusion
CD10, BCL6, CD5, CD23 -
BCL-2 +/-

Question 7

Lymphoplasmacytic lymphoma

Answer 7

> > ?

Question 8

Nodular lymphocyte predominant Hodgkin Lymphoma

Answer 8

CD45+
Strong Pax5 and CD20
CD15 and CD30 -
EMA + in 50%
EBV -
Abundant small B cells
T cell surround LP cells

Question 9

Classical HL

Answer 9

CD45-, occasionally weak CD20+
Weak Pax5 +
CD15, CD30 + (occasionally CD15 - )