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Immunohistochemistry > Immunohistochemistry fruit salad > Flashcards

Immunohistochemistry fruit salad Flashcards

1
Q

Papillary RCC

A

CK7 + (kidney usually CK7 and 20 -)
Racemase +
CAIX -

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2
Q

Chromophobe (vs oncocytoma)

A

Hales colloidal iron: Chromophobe = cytoplasmic staining, oncocytoma = negative or apical blush

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3
Q

Kidney MEST

A

Stroma ER/PR +, Desmin +, SMA +, CD10 +

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4
Q

Seminoma

A 
PLAP +
CD117 +
OCT 3/4 +
CK - or patchy
SALL4 +
HCG + in syncytiotrophpblast cells
EMA -
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5
Q

Spermatocytic tumour

A

CK maybe + (perinuclear, dotlike)
PLAP - or focally +
AFP, HCG, CEA -

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6
Q

Embryonal carcinoma

A

PLAP + (patchy)
CD30 +
EMA -

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7
Q

Yolk sac tumour

A

PLAP + (variable)

AFP

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8
Q

Choriocarcinoma

A

HCG - esp in syncytiotrophoblast
EMA and CK +
CEA and PLAP maybe

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9
Q

Thyroid medullary carcinoma

A 
TTF1 +
Thyroglobulin -
PAX 8 +/-
Calcitonin +
NE markers +
Amyloid deposits - congo red +
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10
Q

Olfactory neuroblastoma

A

CK - (or focal)
EMA -
NE markers +
S100 + stromal/sustentacular cells

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11
Q

Acinic cell carcinoma of salivary gland

A

PAS + granules, diastase resistant

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12
Q

Salivary duct carcinoma

A

Androgen receptor +
GCDFP +
Her2 may be amplified

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13
Q

Osteosarcoma

A

SATB2 - osteoblast transcription factor -useful when histological features of matrix are equivocal

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14
Q

Skin perineurioma

A

EMA+
Claudin1 +
CD34 +/-
S100 -

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15
Q

Adrenal cortical tumours

A

Inhibin and Calretinin +

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Immunohistochemistry (5 decks)

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