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Hematology and Oncology ERIN > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

Divisions of lymphoma

A

Hodgkins and non-hodgkins

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2
Q

Divisions of non-hodgkins lympoma

A 
Follicular lymphoma
Mantle cell lymphoma
Marignal zone lymphoma
Burkitt lymphoma
Diffuse large B cell lymphoma
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3
Q

What cells proliferate in follicular lymphoma?

A

small b cells

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4
Q

Pathophys of follicular lymphoma?

A

proliferatino of small B cells (CD20+) form follicle-like nodules
Translocation results in overexpression of Bcl2 and loss of apoptosis

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5
Q

Which translocation is present in follicular lymphoma?

A

t(14:18) - Bcl2 is translocated to location of it heavy chain locus result in overexpression and prevention of cell death

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6
Q

Treatment of follicular cell lymphoma

A

reserved for patients with symptoms

Rituximab (anti-CD20 antibody)

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7
Q

How to dinstinguish between follicular cell lymphoma and reactive follicular hyperplasia?

A

Follicular cell lymphoma has disruption of normal lymph architecture, lack of tangible body macrophages in germinal center, bcl2 overexpression and monoclonality

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8
Q

What proliferates in mantle cell lymphoma?

A

Small b cells (CD20+)

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9
Q

Which area of the lymph node expands in mantle zone lymphoma?

A

Mantle zone

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10
Q

Which translocation is present in mantle cell lymphoma?

A

t(11:14)
- cylcin D1 on chromosome 11 translocation to it heavy chain locus of chromosome 14 leading to overexpression of cyclin D1

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11
Q

What does the t(11:14) seen in mantle cell lymphoma result in?

A

Overexpression of Cyclin D1 and progression from G1 to S phase

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12
Q

What is marginal zone lymphoma a proliferation of?

A

small b cells (cd20+)

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13
Q

Which zone is expanded in marginal zone lymphoma?

A

Marginal zone

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14
Q

What is marginal zone lymphoma associated with?

A

Chronic inflammatory states including Hashimoto thyroiditis, Sjorgren, H pylori gastritis

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15
Q

what type of lymphoma is MALToma?

A

marginal zone lymphoma of mucosal sites

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16
Q

which translocation may be seen in marginal zone lymphoma?

A

t(11;18)

17
Q

What non hodgkins lymphomas have overexpression of small B cells?

A

follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma

18
Q

Which non hodgkins lymphoma has overexpression of intermediate-b cells?

A

Burkets lymphoma

19
Q

which cells proliferate in burkitts lymphoma?

A

intermediate-sized b cells (cd20+)

20
Q

what is burkitt lymphoma associated with?

A

EBV

21
Q

classic presentation of burkitt lymphoma

A

extranodal mass in child or young adult

22
Q

What are the two forms of burkitt lymphoma?

A

African form - involves jaw

Sporadic form - involves abdomen

23
Q

What translocation drives burkitt lymphoma?

A

t(8;14)

c-myc gene is translocated to igheavy chain locus on chromosome 14 resulting in overexpression of c-myc oncogene

24
Q

What will burkitts lymphoma look like histologically?

A

high mitotic index and ‘starry sky’ appearance

25
Q

what cells proliferate in diffuse large b-cell lymphoma?

A

large B cells (CD20+)

26
Q

histological appearance of large b-cell lymphoma

A

diffuse growth in sheets

27
Q

Hodgkins lymphoma has which type of cell?

A

Reed-sternberg cells

28
Q

What are reed-sternberg cells?

A

Cell type seen in hodgkins lympoma

they are large B cells with multilobed nuclei and prominent nucleoli ‘Owl eyed’

29
Q

Which markers are reed-sternberg cells + for?

A

CD15 and CD30

30
Q

Pathophys of hodgkins lymphoma

A

reed-sternberg cells secrete cytokines which draws in other cell types
May result in B cell symptoms (fever, chills, weight loss, night sweats)
May lead to fibrosis

31
Q

What are the subdivisions of Hodgkins lymphoma?

A

Mixed-cellularity hodgkins lymphoma
Lymphocyte-depleted hodgkins lymphoma
Nodular sclerosis
Lymphocyte-rich hodgkins lymphoma

32
Q

Which type of hodgkins lymphoma is the most common?

A

Nodular sclerosis (70%)

33
Q

Nodular sclerosis hodgkins lymphoma presentation?

A

enlarging cervical or mediastinal lymph node in a young adult female

34
Q

Nodular sclerosis hodgkins lymphoma histology?

A

Bands of sclerosis with reed-sternberg cells in lacunar spaces

35
Q

Which subtype of hodgkins lymphoma has the best prognosis ?

A

Lymphocyte-rich

36
Q

Which subtype of hodgkins lymphoma is the most aggressive and which populations does it effect?

A

Lymphocyte-depleted

seen in elderly and HIV positive individuals

37
Q

Which cell type is abundant in mixed-cellularity hodgkins lymphoma?

A

eosinphils drivin by IL-5 produced by RS cells

Hematology and Oncology ERIN (12 decks)

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