Leukopenia and leukocytosis

Question 1

treatment of leukopenia

Answer 1

GM-CSF or G-CSF to boost granulocyte production

Question 2

Causes of leukopenia

Answer 2

Drug toxicity

Severe infection

Question 3

Causes of lymphopenia

Answer 3

immunodeficiency (digeorge)
high cortisol state
autoimmune destruction
whole body radiation

Question 4

Causes of leukocytosis

Answer 4

Bacterial infection or tissue necrosis

high cortisol state-impairs leukocyte adhesion leading to release of marginated pool

Question 5

What indicates that neutrophils are immature (left shift)?

Answer 5

decreased Fc receptors (CD16)

Question 6

Cause of monocytosis

Answer 6

chronic inflammatory states (autoimmune and infectious) or malignancy

Question 7

Causes of eosinophila

Answer 7

allergic reactions
parasitic infections
hodgkins lympoma via release of IL5

Question 8

causes of basophila

Answer 8

chronic myeloid leukemia

Question 9

causes of lymphocytic leukocytosis

Answer 9

Viral infections

Bortedella pertussis -produces lymphocyte-promoting factor which blocks lymphocytes from leaving blood

Question 10

two VIRAL causes of lymphocytic leukocytosis ?

Answer 10

EBV and infectious mononucleiosis

Question 11

Where does EBV infect?

Answer 11

B cells
oropharynx
liver

Question 12

Pathophys of EBV

Answer 12

CD8 cell response causes generalized lymphadenopathy due to t-cell hyperplasia in lymph node paracortex
-this also leads to splenomegaly

Question 13

Which test is used to identify EBV?

Answer 13

Monospot test- detects igM antibodies that cross react with sheep or horse RBCs (heterophile antibodies)

Question 14

What does a negative monospot test suggest?

Answer 14

CMV may be cause

Question 15

Definitive test for EBV?

Answer 15

serologic testing for EBV viral capsid antigen

Question 16

Complications of EBV?

Answer 16

Increased risk for splenic rupture
Rash if exposed to ampicillin
Dormany of virus in B cells may lead to risk of recurrence and B-cell lymphoma