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Haematology Year 3 > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

what is a lymphoma

A

malignant lymphocytes that accumulate in the lymph node

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2
Q

sub divisions of lymphoma

A

Hodgkin lymphoma

Non-Hodgkin lymphoma

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3
Q

what can cause a lymphadenopathy? (enlarged lymph node)

A

lymphoma
infection( viral/bacterial)
metastatic cancer e.g. breast
connective tissue disease e.g. sarcoidosis

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4
Q

what would a lymph node feel like in bacterial infection

A

tender, hard, smooth, inflamed skin

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5
Q

what would a lymph node feel like in a viral infection

A

tender, hard, smooth, mobile

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6
Q

what would a lymph node feel like in a lymphoma

A

non tender, rubbery/soft, smooth, mobile

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7
Q

what would a lymph node feel like in a metastatic carcinoma

A

non tender, hard, irregular, fixed

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8
Q

what is performed if a lymphoma or metastatic carcinoma is suspected

A

FNA or core needle biopsy

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9
Q

symptoms of a lymphoma

A 
fever
night sweats
weight loss
itch 
alcohol induced pain 
fatigue
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10
Q

after a lymphoma has been confirmed, what needs to be done to help subclassify

A

immunohistochemistry – looks at pattern of proteins on the surface of lymphoma cells

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11
Q

4 subtypes of Hodgkin disease that can be differentiated from histology

A

nodular sclerosis
lymphocyte rich
mixed cellularity
lymphocyte depleted

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12
Q

what cell type is seen in Hodgkin lymphoma

A

Reed Sternberg cells

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13
Q

which immuno markers are +ve for Reed Sternberg cells

A

CD30

CD15

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14
Q

types of non-hodgkin lymphoma

A

T cell

B cell

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15
Q

which type of non-hodgkin lymphoma is most common

A

B cell (90%)

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16
Q

immunomarker for follicular non-hodgkin lymphoma

A

CD20

17
Q

what is B cell non-hodgkin lymphoma further divided into

A

Low grade B cell

High grade B cell

18
Q

which is more common - Hodgkin or non-hodgkin lymphoma

A

non-hodgkins

19
Q

mean age of non-hodgkin lymphoma presentation

A

50

20
Q

who gets Hodgkin lymphoma

A

young adults 20-34

>70 year olds

21
Q

what virus is associated with Hodgkin lymphoma

A

EBV

22
Q

how is lymphoma staged

A

1 = one group of affected glands above the diaphragm

2= more than one group of glands either above OR below the diaphragm

3= glands both above and below the diaphragm

4= extra nodal disease

23
Q

what is burkitts lymphoma

A

High grade B cell lymphoma
occurs in africa- associated with malaria and EBV
very sensitive to chemotherapy

Haematology Year 3 (21 decks)

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