Lymphatic Viruses Flashcards
Protein present in envelope of Ebola
GP protein
Protein present in matrix space of Ebola
VP40, VP24
Protein present in nucleopcapsid of Ebola
NP, VP35, L, VP30
Shape of Ebola
filamentous, pleomorphic (U-shaped, 6-shaped), flexible with extensive branching
Transmission of Ebola Virus
Direct contact, raw meat consumption, sexual contact, breast milk
Hepatocellular necrosis leads to _____
Reduced synthesis of clotting factors
These body fluids may serve as a transmission for ebola
- Blood
- Sweat
- Vomit
- Urine
- Feces
- Sputum
- Semen
Clinical signs of Ebola
- Fever
- myalgia
- headache
- malaise
- abdominal pain
- epistaxis
- vomiting
- loss of appetite
- rash
- diarrhea
- red eyes
Diagnosis of Ebola
- ELISA
- RT-PCR
- Next generation sequencing
_____ is the gold standard in Ebola diagnosis
RT-PCR
Next genomic sequencing is vital for _____
identification of viral variants
Ebola species which do not infect humans
Resron ebolavirus (RESTV)
Ebola Virus species with highest percent mortality
Zaire ebolavirus (EBOV)
Ebola virus species where primates are the most susceptible animals
Tai Forest Ebolavirus (TAFV)
Ebola virus species with 2 approved vaccines
Zaire ebolavirus
TRUE OR FALSE: Supportive therapy should be paired with antivirals.
FALSE, supportive therapy only
Order of Cytomegalovirus
Herpesvirales
Family of cytomegalovirus
Herpesviridae
Subfamily of cytomegalovirus
Betaherpesvirinae
Prominent structures of cytomegalovirus
- outer lipid envelope
- tegument
- nucleocapsid
- internal nucleoprotein core
Typical mononucleosis syndrome
acute febrile illness with an increase of 50% or more in lymphocytes/monocytes
Cytomegalovirus infections are mostly ______
subclinical, lifelong infections
Transmission of CMV
- Direct contact
- breast milk
- pregnancy
- sexual contact
- organ transplant and blood transfusion
Epidemiological factors for CMV
- Geographical location (developing countries)
- Age (older)
- Socioeconomic status (crowded and poorer communities)
