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152 LE 5 > Lymphatic Viruses > Flashcards

Lymphatic Viruses Flashcards

1
Q

Protein present in envelope of Ebola

A

GP protein

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2
Q

Protein present in matrix space of Ebola

A

VP40, VP24

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3
Q

Protein present in nucleopcapsid of Ebola

A

NP, VP35, L, VP30

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4
Q

Shape of Ebola

A

filamentous, pleomorphic (U-shaped, 6-shaped), flexible with extensive branching

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5
Q

Transmission of Ebola Virus

A

Direct contact, raw meat consumption, sexual contact, breast milk

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6
Q

Hepatocellular necrosis leads to _____

A

Reduced synthesis of clotting factors

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7
Q

These body fluids may serve as a transmission for ebola

A
  • Blood
  • Sweat
  • Vomit
  • Urine
  • Feces
  • Sputum
  • Semen
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8
Q

Clinical signs of Ebola

A
  • Fever
  • myalgia
  • headache
  • malaise
  • abdominal pain
  • epistaxis
  • vomiting
  • loss of appetite
  • rash
  • diarrhea
  • red eyes
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9
Q

Diagnosis of Ebola

A
  • ELISA
  • RT-PCR
  • Next generation sequencing
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10
Q

_____ is the gold standard in Ebola diagnosis

A

RT-PCR

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11
Q

Next genomic sequencing is vital for _____

A

identification of viral variants

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12
Q

Ebola species which do not infect humans

A

Resron ebolavirus (RESTV)

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13
Q

Ebola Virus species with highest percent mortality

A

Zaire ebolavirus (EBOV)

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14
Q

Ebola virus species where primates are the most susceptible animals

A

Tai Forest Ebolavirus (TAFV)

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15
Q

Ebola virus species with 2 approved vaccines

A

Zaire ebolavirus

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16
Q

TRUE OR FALSE: Supportive therapy should be paired with antivirals.

A

FALSE, supportive therapy only

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17
Q

Order of Cytomegalovirus

A

Herpesvirales

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18
Q

Family of cytomegalovirus

A

Herpesviridae

19
Q

Subfamily of cytomegalovirus

A

Betaherpesvirinae

20
Q

Prominent structures of cytomegalovirus

A
  • outer lipid envelope
  • tegument
  • nucleocapsid
  • internal nucleoprotein core
21
Q

Typical mononucleosis syndrome

A

acute febrile illness with an increase of 50% or more in lymphocytes/monocytes

22
Q

Cytomegalovirus infections are mostly ______

A

subclinical, lifelong infections

23
Q

Transmission of CMV

A
  • Direct contact
  • breast milk
  • pregnancy
  • sexual contact
  • organ transplant and blood transfusion
24
Q

Epidemiological factors for CMV

A
  • Geographical location (developing countries)
  • Age (older)
  • Socioeconomic status (crowded and poorer communities)
25
Q

Diagnosis for CMV

A
  • Serology
  • Viral culture
  • antigenemia
  • molecular
26
Q

Treatment for CMV _____ CMV replication but _____ the virus

A

halt, do not eliminate

27
Q

______ treatment has poor bioavailability orally

A

ganciclovir

28
Q

Epstein-barr virus is also called as ____

A

human gammaherpesvirus 4

29
Q

This virus is the infectious agent for kissing disease/mono/infectious mononucleosis

A

Epstein-Barr

30
Q

Order of Epstein-Barr Virus

A

Herpesvirales

31
Q

Family of Epstein-Barr Virus

A

Orthoherpesviridae

32
Q

Subfamily of Epstein-Barr Virus

A

Gammaherpesvirinae

33
Q

Tropism of Epstein-Barr Virus

A

B cells and epithelial cells

34
Q

Order of EPV pathogenesis

A

Saliva - Oropharynx - Pharyngeal epithelial cells

35
Q

Lymphoma-Associated Disorders common in Chinese males aged 20-50 y/0

A

Nasopharyngeal carcinoma

36
Q

Lymphoma-Associated Disorders with aggressive B-cell lymphoma

A

Burkitt’s

37
Q

Patients with HIV infected with CMV would have CMV-induced end-organ damage most commonly in the form of ____

A

retinitis

38
Q

(+), icosahedral nucleocapsid with linear dsDNA

A

CMV

39
Q

Ganciclovir is preferred administered _____

A

intravenously

40
Q

Epidemiological factors of CMV

A
  • Geographic location
  • Age
  • Socioeconomic status
41
Q

Lymphoma is the ___

A

lack of effective immune response

42
Q

Lymphoma-Associated Disorders

A

● B-cell tumors in immunocompromised patients
● Hodgkin lymphoma
● Nasopharyngeal carcinoma
● Burkitt’s lymphoma

43
Q

Co-factor of Burkitt’s lymphoma

A

Malaria

44
Q

Gold standard for EPV diagnosis

A

Serology

152 LE 5 (6 decks)

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