Lymphatic System Flashcards

1
Q

The lymphatic system

A

Made up of a series of vessels and organs. These vessels are separate to the arteries and veins.

Found throughout the body

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2
Q

anatomy and physiology

A
lymph
Lymph vessels
lymph nodes
Lymph organs
diffuse lymphoid tissue
Bone marrow
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3
Q

bone marrow children v adults

A

Children have more bone marrow than adults.

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4
Q

what are the three functions of the lymphatic system

A

Draining excess interstitial fluid (fluid around the cells that make up a tissue)

transporting fats and fat soluble vitamins from the gastrointestinal tract

Immune response to destroy foreign cells and protect against disease.

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5
Q

draining excess interstitial fluid

A

approx. 21 litres of fluid from plasma escape into the tissues from the arterial end of capillaries daily. This becomes interstitial fluid.

This fluid bathes and surrounds cells and separates the cells from circulatory system.

helps bring oxygen and nutrients to cells and to remove waste products from them. As new tissue fluid is made it replaces older fluid which drains towards lymph vessels.

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6
Q

Transporting fats and fat soluble vitamins from the gastrointestinal tract

A

lymph vessels calls lacteals found in the villi of the GI tract. These lacteals remove fats and transport them to the blood stream. This mixture is called chyle. It is a milky white substance formed during digestion of fatty foods.

Chyle consists of a mix of lymphatic fluid and chylomicrons. Chylomicrons serve to transport fat from its port of entry in the intestine to the liver.

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7
Q

mounting an immune response to destroy foreign cels and protect against disease

A

Organs of the lymphatic system are involved in the production of lymphocytes
….

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8
Q

Functions of the lymphatic fluid…

A

immunological protection

Maintains fluid balance

absorbs fats

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9
Q

anatomy and physiology - lymphatic vessels

A

Similar to veins but have thinner walls

lymphatic capillaries are larger than blood capillaries

Lymphatic capillaries are open ended tubes constructed of overlapping endothelial cells. These cells separate when outside pressure exceeds that within the vessel. This allows fluid in but not out.

more valves than veins do

Movement of lymph is facilitated by muscular contraction

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10
Q

Lymph fluid

A

contains a high number of a type pf white blood cells called lymphocytes that fight infection and destroy damaged or abnormal cells.

No RBCs

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11
Q

lymph nodes

A

A lot concentrated around jaw line and neck and under the arm

filter lymph as it goes through

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12
Q

Lymph vessels drain into…

A

drain into two main trunks which empty into the venous system at the subclavian veins:
Right lymphatic duct
thoracic duct

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13
Q

Functions in relation to immunity

A

lymph nodes are termed secondary lymphoid tissues. This is where WBCs are activated.

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14
Q

what are the primary lymphatic organs

A

Where lymphocytes are formed and mature

Two primary: red bone marrow and thymus gland

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15
Q

What do the thymus and bone marrow do?

A

provide an environment for the stem cells (a cell that hasn’t yet differentiated into something) to divide and mature into T cells (in thymus) and B-cells (in bone marrow)

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16
Q

B and T cells - what do they do?

A

T-cells (I attack invaders outside the cells)

B-cells(I attack infected cells)

17
Q

t cells

A

Patrol our bodies and scan for other cells that display foreign peptides that indicate a cell is infected or has become cancerous

directly kill virally or bacterially infected cells

Naturally eradicate cancer cells

activate and help B cells

Remember a pathogen that they encountered decades ago

18
Q

what are the two main types of T cells

A

Helper t cells - help other cells of the immune system by releasing T cell cytokines which help to modulate the immune response.

cytoxic killer T cells - kill virally infected cells and tumours

19
Q

T cells are also responsible for

A

rejection of a transplanted organ
Virtually all autoimmune disease e.g. diabetes, multiple sclerosis)
some allergic reactions e.g. gluten intolerant

20
Q

What are macrophages?

A

a type of WBC, they are the first cells at the site of infection

Help to keep the body free of invaders and can summon additional support from T cells when required.

digest something that shouldn’t be there (phagocytosis). As they eat other cells they are able to pull apart the proteins from this and present them to T cells to show them what it looks like so they know what to attack. T cells enable immune response.

21
Q

B cells

A

Secreting antibodies

bind to surface of invading molecule
Detect surface antigen

22
Q

plasma cells

A

Develop from b cells.

WBCs that secrete large volumes of antbodies

23
Q

what does the spleen do

A

Largest filter of blood

removes old RBCs

Destroy bacteria

synthesises antibodies

24
Q

Innate immunity

A

skin - physical barrier to infection

Macrophages and inflammation

tears - contain lysosomes

Nose - mucous membrane traps bacteria

ciliary mucous -

Diarrhoea - virus flushed from body

25
Q

acquired immunity

A

specific/active: Usually against one specific organism
Exposed to organism first before mounting a response.
recognises the specific antigen > produces specific antibody > develops a memory

passive: babies have passive immunity (moms blood) for 2-4 months

Vaccines: injecting body with weakened pathogen to generate antibody production

26
Q

hodgkins disease/lymphoma

A

Type of cancer of the lymphatic system.

can start almost anywhere in the body

Caused by HIV, age, family history

27
Q

non hodgkins lymphoma

A

Malignant cancer - caused by the body producing too many abnormal white blood cells.

28
Q

lymphadenitis

A

Enlargement of a lymph node, usually due to infection

29
Q

lymphangitis

A

Inflammation of lymph vessels.

30
Q

lymphocytosis

A

High lymphocyte count

31
Q

lymphodeama

A

Chronic pooling of lymph fluid in the tissue due to malfunctioning of the lymph system

32
Q

HIV

A

Infects helper T cells, multiples and moves on

destroys T cells. Loss of these cells makes it hard for the body to fight off infections and certain HIV related cancers.

Cannot be destroyed by WBC as it keeps changing its outer coat

4 stages of HIV