Cardivascular system Flashcards
Blood 3 main functions
RBC, WBC, plasma and platelets
Transportation of oxygen (if not enough oxygen hypoxia, effect at cellular level), c02 (gaseous exchange), nutrients (e.g. glucose), waste, hormones and heat
Regulation of pH levels and regulation of heat (dilation and constriction of blood vessels)
Protection from infection (uses WBC for infection control) and stop you bleeding out through its clotting ability
Physical characteristics of blood
Thicker than water more viscous than water Blood temp is 38 degrees pH is about 7.35-7.45 and therefore slightly alkaline About 7-8% of body weight males have approximately 70mls per kg of blood Females have approx 60mls per kg children have about 80mls per kg Newborn has about 100mls per kg
Blood loss and children
Children can’t afford to loose much blood, so even smallest amount of blood loss can be time critical
Blood formation
Happens in the red bone marrow and is known as haemopoiesis.
Blood components
Plasma - 55% (proteins, water, electrolytes, gases, nutrients)
Cellular formed elements - 45% (platelets, WBC, RBC)
WBC and platelets - <1%
3 main types of blood cells
Erythrocutes (RBC)
Leukocytes (WBC)
Thrombocytes (platelets)
Red blood cells:
Responsible for:
transportation of oxygen from the lungs to the tissues and transportation of small amounts of c02 from the tissues to the lungs
Can change shape and squeeze through smaller blood vessels
are circular bi-concave discs which provides a greater surface area for the transportation of 02 and thus greater diffusion
Do not have a nucleus
life span of 120 days and so regenerated relatively quickly in the body. This is why we can afford to give blood.
Haemoglobin
Oxygen binds on to the haemoglobin on the RBC for transport around the body
it is a complex protein that consists of haem (iron containing part) and globin (protein part)
A fully saturated haemoglobin molecule can carry 4 02 atoms
women tend to require more iron within their diets due to menstruation
worn out RBC are destroyed by the spleen and liver by WBC.
Oxyhaemoglobin
Haemoglobin combines with 02 to form oxyhaemoglobin. This combination gives blood its red colour (shows it is very well oxygenated).
carbaminohaemoglobin
haemoglobin carries 23% of the c02 that is returned from the tissues to the lungs to be breathed out. When it is carrying this c02 it is known as carbaminohaemoglobin.
Carboxyhaemoglobin
When haemoglobin is carrying carbon monoxide
Carbon monoxide binds at the same sites on the haemoglobin molecule as oxygen but it has a greater affinity for haemoglobin than oxygen (210 times greater) and so will attach quicker and more efficiently than oxygen. This is why carbon monoxide poisoning is so dangerous. Body is then not getter any oxygen. Haemoglobin just assumes it is oxygen attached as it doesn’t know the difference.
Thrombocytes (platelets)
Very small non-nucleated discs
can be sticky and are responsible for promoting clotting and the clotting process.
Life span approx 8-11 days
derived from cytoplasm found in the red bone marrow
Blood clotting process:
- You injured yourself. This process damages the platelets, causing them to release an enzyme called thrombokinase
- Thrombokinase and prothrombin combine with calcium salts to form thrombin
- Thrombin converts fibrinogen into fibrin
- Fibrin threads form a mesh and entrap formed elements creating a clot.
This is coagulation.
what is coagulation
This is the development of a network of insoluble protein fibres in which the formed elements are trapped thus preventing further blood loss.
Blood clotting process, what does it do?
Stops blood getting out and infection getting in
Can sometimes happen when we don’t want it to e.g. blood clot in artery, causing heart attack, stroke, pulmonary embolism
some people don’t have the ability to clot and so need medication
WBC
combat infection and inflammation
live from hours to days
Contain a nucleus
WBC count will increase due to various events including: strenuous excercise, pregnancy, surgery, infection, stress, leukaemia, tissue damage i.e. burns.
What are the two main types of WBC?
Granular - granules in cytoplasm produced in bone marrow. Generally enzymes e.g. neutrophils
Agranular - no or few granules, produced in lymph tissue e.g. lymphocytes
Blood grouping
AB, A, B, O
Depends on what antigens you have on your RBCs
O - universal donor because they have no antigens. Therefore, they do not react with other blood groups. But you do have A and B antibodies.
AB - universal recipient. Have both A and B antigens on your RBCs. No antibodies.
5 types of blood vessel are?
Artery Arteriole Capillary Vein Venule
Blood vessel structure
Tunica Adventitia
Tunica media
Tunica intima
Blood vessel diameter regulated by?
Regulated by the smooth muscle of the tunica media which is innervated only by the sympathetic nerves, not parasympathetic.
Sympathetic activity acts to constrict, therefore diameter is regulated by the degree of sympathetic activity.
Elasticity in veins
Much less than in arteries.
Arteries are carry oxygenated blood away from heart to the rest of the body at high pressure to get all the way around the body. Therefore, need more elasticity than veins which carry blood at lower pressure.
The heart
Cone shaped, around the size of the owners clenched fist.
weighs approx. 200 grams in a male and 250 grams in a female.
What is the mediastinum?
The block of tissue in the centre of the lungs. (Lungs, heart, all the pieces of tissue that make up these). Extends from the sternum to the vertebral column and lies between the linings of the two lungs.
the heart rests on the diaphragm, near the midline of the thoracic cavity, within the mediastinum.
approx. 2/3 of the heart lies to the left of the midline of the body.
Anatomical lie of the heart
pointed end of the heart is known as the apex
Apex projects anteriorly, inferiorly and to the left
broad portion of the heart is known as the base. This projects posteriorly and superiorly to the right.
The inferior portion of the heart I.e. the apex, lies on the diaphragm.
superior to the heart are the great blood vessels (vena cava, aorta)
Posterior to the heart is the oesophagus, trachea and the left and right bronchus
laterally to the heart, lie the lungs
Anteriorly lie the sternum, ribs and intercostal muscles.