Lymphatic System Flashcards
How much interstitial fluid does the lymphatic system collect per day?
3L
How much interstitial fluid does the lymphatic system collect per day?
3L
Where are there no lymphatics?
CNS
What is cellulitis?
An infection of the deeper layers of the skin and underlying tissue
What is an ulcer?
A break in the continuity of the epithelium
What is MALT?
Mucosal associated lymphatic tissue
Name some lymphatic nodules
Tonsils, peyers patches, appendix
Name some lymphatic organs
Lymph nodes, thymus, spleen
Where in the GI system are there lots of lymphatics?
Small bowel particularly the ileum
What are peyers patches?
Organised lymphoid nodules (aggregations of GALT)
Where can peyers patches be found?
In the ileum
What is lymph node flow aided by?
Adjacent skeletal muscle
Adjacent arteries
Pressure changes in thorax
Is the liver part of the lymphatic system?
No
Where do the afferent lymphatics arrive to in the LN?
Convex surface
How to the efferent lymphatics leave the LN?
Hilum
How are lymphatic nodules arranged?
Germinal centres and outer cortex
Where are follicular dendritic cells found?
Germinal centres
What do dendritic cells cause?
Proliferation of B cells
Name some professional APCs?
B cells and macrophages
What cells mediate inflammation?
Macrophages and neutrophils
What mediates the humoral response?
B cells - produce antibodies
What cell medicates the cell mediated response?
T cell
Why do LN swell in response to infection?
Germinal centres fill with lymphocytes
Roles of the spleen
Antigen presentation
Activation of b and t cells
Remove old and abnormal RBC and platelets
Retrieval of iron from RBC
What is there a risk of post splenectomy?
Increased risk of infection by encapsulated bacteria
Increased risk of DVT and PE
Where is the thymus found?
Superior mediastinum
What is the role of the thymus?
Thymic cell education
Maturation of bone marrow derived stem cells into immunocompetent t cells
Where are there no lymphatics?
CNS
What is cellulitis?
An infection of the deeper layers of the skin and underlying tissue
What is an ulcer?
A break in the continuity of the epithelium
What is MALT?
Mucosal associated lymphatic tissue
Name some lymphatic nodules
Tonsils, peyers patches, appendix
Name some lymphatic organs
Lymph nodes, thymus, spleen
Where in the GI system are there lots of lymphatics?
Small bowel particularly the ileum
What are peyers patches?
Organised lymphoid nodules (aggregations of GALT)
Where can peyers patches be found?
In the ileum
What is lymph node flow aided by?
Adjacent skeletal muscle
Adjacent arteries
Pressure changes in thorax
Is the liver part of the lymphatic system?
No
Where do the afferent lymphatics arrive to in the LN?
Convex surface
How to the efferent lymphatics leave the LN?
Hilum
How are lymphatic nodules arranged?
Germinal centres and outer cortex
Where are follicular dendritic cells found?
Germinal centres
What do dendritic cells cause?
Proliferation of B cells
Name some professional APCs?
B cells and macrophages
What cells mediate inflammation?
Macrophages and neutrophils
What mediates the humoral response?
B cells - produce antibodies
What cell medicates the cell mediated response?
T cell
Why do LN swell in response to infection?
Germinal centres fill with lymphocytes
Roles of the spleen
Antigen presentation
Activation of b and t cells
Remove old and abnormal RBC and platelets
Retrieval of iron from RBC
What is there a risk of post splenectomy?
Increased risk of infection by encapsulated bacteria
Increased risk of DVT and PE
Where is the thymus found?
Superior mediastinum
What is the role of the thymus?
Thymic cell education
Maturation of bone marrow derived stem cells into immunocompetent t cells
