Lymphatic System 3 Flashcards
(29 cards)
Macrophages
Monocytes that develop into phagocytic cells after leaving the blood
Phagocytic cell formed by bone marrow that migrate to epithelial tissues
Dendritic cells (DC)
Monoclonal antibodies
Specific antibodies produced or derived from a population or culture of identical cells
Hybridomas
Lymphocytes are fused with cells that are transformed to grow indefinitely and continue to produce the same antibody as the original lymphocyte
Macrophages and DCs act as ______ by removing an ingested cells antigens and displaying them on their cells surfaces
Antigen presenting cells
Cells ultimately responsible for antibody production
Lymphocytes
2 designated types of lymphocytes
B and T cells
All lymphocytes that circulate in the tissues arise from primitive cells in bone marrow called
Stem cells
First stage of B cell development
Formation of stem cells into immature B cells
Where does the formation of stem cells into immature B cells occur
In the liver and bone marrow before birth, but only in the bone marrow in adults
Chief place of residence for B cells
Lymph nodes
Second stage of B cell development
Changes mature, but inactive B cell, into an active B cell
A family of many identical cells, all descended from one cell
Clone
Two kinds of cells in each B clone
Plasma cells (effector cells) and memory cells
Secrete huge amounts of antibodies into the blood
Plasma cells
Remain in reserve in the lymph nodes until contacted by the same antigen that led to their formation
Memory cells
Function of B cells
Function indirectly to produce humoral immunity
“Antibody factories” of the body
Plasma cells
Where are the antibodies formed in the plasma cell?
On the ER of the cell
Where do T cells undergo their first stage of development
Thymus gland
Where do T cells chiefly migrate?
Lymph nodes
When does the second stage of development for a T cell occur?
When it comes into contact with its antigen
T cell reproduction and defense is similar to
B cells
Function of T cell
Produce cell- mediated immunity