Lymphatic pump treatment DSA Flashcards
Recent studies show what about lymphatic pump procedures?
LPT applied to rats and dogs does increase lymph flow
animal experiments show that LPT also increases the concentration of leukocytes in lymph
LPT stimulates the mobilization of GALT-derived leukocytes into the lymphatic circulation and the release of leukocytes from mesenteric lymph nodes
function of lymphatic system
helps maintain extravascular homeostasis by transporting excess fluid and substances from the interstitial space to the blood circulation
lymph can contain
immune cells, apoptotic cells, proteins, infectious organisms and antigens that exist in the interstitial space.
Movement of lymph
maintained by pressure gradients
aided by phasic contractions of smooth muscle in lymph vessel walls
valves prevent backflow
Factors influencing lymph flow
lymphangions between valves cyclically contract (pump) when engorged
NO release from lymphatic endothelium reduces hydraulic resistance
skeletal muscle contraction, intestinal motility and respiratory motions increase lymphatic transmural pressure, compress lymph vessels and increase flow.
LPT is used clinically to
treat patients with CHF, GI dysfunction, respiratory tract infection, and edema.
greatest increases in lymph flow in dog experiments was seen in
abdominal pump and exercise
splenic pump treatments
increases the antibody titer
splenic manipulation increases leukocyte count and serum opsonic index against Mycobacterium tuberculosis.
In people vaccinated against strep pneumo, lymph pump treatment…
increased hemagglutination against bacterial cells and bacterial polysaccharide antigens
in Hep B vaccines, the LPT group also had igher protective antibody titers compared to the control group
In mammalian species, the majority of lymphocytes in thoracic duct lymph are derived from
the GALT.
LPT significantly increases the numbers of macrophages, neutrophils, CD4+ T cells, CD8+ Tcells, IgA+ B-cells and IgG+ B cells in both thoracic and mesenteric duct lymph.
IgA and IgG B cells suggests LPT is able to stimulate the release of mature, isotype-switched B cellsf rom the GALT into the lymphatic circulation.
lymphatic pump treatments and protection against infectious disease
as abx grow less effective, growing need to re-examine benefits of alternatives such as LPT
LPT and tumors
reduces the size of solid tumors
earliest success recorded for the use of osteopathic med to treat infectious disease
H1N1 influenza pandemic of 1917-18
mortality rate of OMT treated cases- only .24% as compared to national mortality rate of 3-5%
LPT and lower respiratory tract disease
more rapid cleansing of the tracheobronchial tree
increased sputum production
shorter duration of cough
hospitalized elderly patients with acute pneumonia and LPT/ OMT
reduced the need for intravenous abx and reduced length of hospital stay
