CIS Peds Lower Resp (Lopez, Oct 27) Flashcards
3 factors in asthma
obstruction+ inflammation + autonomic imbalance
Asthma: Background
obstructive pulmonary disease w/ inflammatory component
The dynamic balance of sympathetic and parasympathetic influences in the lung is distorted in asthma
Aspects of anatomical and physiological immature in young children with asthma result in vulnerability for respiratory muscle fatigue, inefficiency of diaphragmatic mechanics, and ineffectiveness of tissue recoil
There are biomechanical, respiratory-circulatory, metabolic, and neurological influences that need to be considered in the management of asthma
Osteopathic manipulative medicine used in conjunction with standard care may improve the severity of asthma symptoms and decrease the need for pharmaceutical management
Triggers
cold/ weather changes exercise viral respiratory infections medications (ASA, NSAIDs) Allergens Pollution/ smoke Emotional stress GERD Mechanical injuries
Hypersensitivity reaction
inflammation –> edema
bronchospasm
mucous plugging
Bronchial smooth muscle is innervated by vagus nerve; vasovagal reflexes can cause bronchoconstriction; overactivity of the bronchial branches of the vagus nerve can worsen the issue
Airway obstruction
difficulty breathing wheezing nighttime cough prolonged expiratory phase air trapping
Repetitive episodes of inflammation
lead to a production of matrix proteins and growth factors that can potentially cause airway remodeling
Remodeling + increased muscle mass + mucosal edema + reduced elasticity –> decreased efficacy of bronchodilators and decreased O2:CO2 exchange
Osteopathic Management of asthmatic patient
Start or continue pharmacological management according to asthma severity and state of exacerbation
Optimize breathing mechanics (Biomechanical Model)
Normalize autonomic nervous system (Neurologic Model)
Optimize respiratory/ circulatory/ lymphatic function (Respiratory/ Circulatory Model)
Optimize lifestyle and diet (Metabolic Model)
Remove barriers to health: identify and minimize triggers, educate patient in proper usage of medications, help patient obtain medications, etc. (Behavioral Model)
Asthma: Initiating Therapy
Intermittent asthma - step 1 (short acting beta-2 agonist)
Mild persistent asthma - step 2 (low-dose inhaled corticosteroid)
Moderate persistent asthma - step 3 (medium-dose inhaled corticosteroids option) and consider short course of oral corticosteroids
Severe persistent asthma - step 3 (medium-dose inhaled corticosteroids option) or 4 and consider short course of oral corticosteroids
Evaluate level of asthma control in 2-6 weeks and adjust therapy accordingly
Asthma: Treatment During Exacerbation
Increasing frequency of short-acting beta-2 agonists
Possibly start oral steroids
Consider starting inhaled steroids
Give oxygen to maintain O2 sat >90-92%
Ipratropium in ED patients refractory to initial short-acting beta-2 agonist
Magnesium sulfate may be considered to avoid intubation
Intubation for impending respiratory failure, apnea, or coma
Biomechanical Model:Effects of Airway Obstruction
A child with an obstructive airway suffers from:
Increased effort to maintain normal air movement through bronchioles
Decreased mechanical effectiveness of diaphragm and rib cage
- Children have a flatter diaphragm than adults
- Rib cage is more flexible than adults
Increased O2 demand and waste production
- Alters pH
Increased work of breathing
Biomechanical Model: Treatment Goals
OMT: to decrease work of breathing by facilitating mechanics
- Facilitate normal motion of thoracic cage and pelvic diaphragm
- Remove fascial, bony and ligamentous restrictions
- Decrease muscle hypertonicity of primary and accessory muscles of respiration
Breathing exercises that strengthen peripheral and accessory muscles that aid breathing and facilitate exhalation
Yoga, tai chi, noncontact martial arts that integrate breathing with movement
The Thoracic Diaphragm:
Primary muscle of respiration
Alters arterial and venous circulation
– Fluid movement through vena cava dependent on effective diaphragmatic excursion
Alters lymphatic circulation
Moves extracellular fluid in abdomen into lymph system
– Removal of cellular waste
Respiratory-Circulatory Model
Respiration is a constant and powerful modulator of cardiovascular control
During breathing, the diaphragm reduces negative intrathoraic pressure through inhalation, enhancing venous drainage
Lymphatic flow depends on rhythmicity and stretching of diaphragm, then on intraperitoneal pressure and posture of the individual
Cisterna chyli, located under diaphragmatic crural region, main destination point for lymph
goals of Respiratory-Circulatory Model
Restore optimal motion at the diaphragm and pelvic diaphragm
Remove restrictions to lymphatic, arterial, and venous systems
– Including Thoracic Outlet Release
Neurologic Model and asthma
Asthmatics suffer from an imbalance of the autonomic nervous system
Smooth muscles are innervated by sympathetic, parasympathetic, and primary afferent fibers
Vagus nerve –> Jugular foramen –> Cervicals –> Thoracic inlet –> Lungs
Sympathetics to lungs: T1-6
– Viscerosomatic reflexes/ Facilitated segments
Somatic dysfunction may lead to/ be a result of imbalance of the neuroendocrine immune system resulting in more inflammation