Lymphadenopathy Flashcards
What symptoms suggest lymphoma?
Pruritus without rash
Painful lymph nodes following alcohol consumption
What causes tender lymph nodes?
Viral infection
Bacterial infection
What do ‘rubbery’ lymph nodes suggest?
Lymphoma
What do irregular, hard lymph nodes suggest?
Metastatic cancer
What form of cancer can involve blood, bone marrow AND lymph nodes?
Chronic lymphocytic leukaemia (CLL)
How is lymphoma diagnosed?
Excision biopsy
This is the only way to diagnose this - immunohistochemistry can be used to back up diagnosis.
What does the presence of nodular sclerosis on biopsy indicate?
Hodgkin’s lymphoma
Following diagnosis of lymphoma, what is performed?
CT scan of chest, abdomen and pelvis for signs of spread.
What staging system is used in lymphoma?
Ann Arbor staging
What does serum LDH indicate?
Cellular necrosis.
This is a non-specific sign.
When does Hodgkin’s Lymphoma present?
20s-30s
What infection is linked to the development of Hodgkin’s lymphoma?
Ebstein-Barr infection.
How does Hodgkin’s Lymphoma spread?
Spreads in an orderly fashion.
Affects a full lymph group before spreading.
What is the hallmark cell of HL?
Reed-Sternberg cells.
These are not always observed in HL, but indicate this as diagnosis when present.
How are all forms of lymphoma treated?
Multi-agent chemotherapy and radiotherapy.
