Lymph stuff & the spleen

Question 1

What is usually the consistency of affected lymph nodes in lymphoma?

Answer 1

Rubbery/soft

Question 2

How does high grade differ from low grade NHL on histology?

Answer 2

High grade has more immature looking cells

Question 3

What cell marks Hodgkin’s lymphoma on immunohistochemistry?

Answer 3

CD30 +ve Reed Sternberg cells

Question 4

Where within a lymph node is lymph filtered before return to the blood stream?

Answer 4

Parenchyma

Question 5

In what types of condition is the immune reaction in a lymph node predominantly B-cells?

Answer 5

Auto-immune

Infection

Question 6

In what condition is the immune reaction in a lymph node predominantly phagocytic?

Answer 6

Draining a tumour site

Question 7

What is the function of the spleen?

Answer 7

Filter the blood

Facilitate immune response to blood borne anitgens

Question 8

Which part of the spleen is mainly responsible for immune response?

Answer 8

White pulp (PALS0 - CD4+ lymphoid cells

Question 9

What is the triad of hypersplenism?

Answer 9

Splenomegaly
Fall in one ro more cellular components of blood
Correction of cytopenias by splenectomy

Question 10

Causes of hyposplenism?

Answer 10

Splenectomy
Coeliac disease
Sickle cell disease
Sarcoidosis

Question 11

What are the lab features of hyposplenism?

Answer 11

Reduced ed pulp function (Howell-Jolly bodies)