Bleeding Disorders Flashcards
What can cause failure of primary haemostasis?
Vascular
Reduced number of platelets (thrombocytopenia)
Reduced platelet function
Von Williebrand Factor
What vascular abnormalities can cause faiolure of haemostasis?
Marfans (less collagen)
HSP
How does HSP present?
Fresh PR bleeding in children
Autoimmune
Self limiting with supportive care
What are the causes of peripheral platelet destruction?
Coagulopathy (DIC)
Autimmune (immune thrombocytopenic purpura)
Hypersplenism
What is renal failure interferes with platelets function?
Urea
How is VWF deficiency inherited?
Autosomal dominant
What is the commonest cause of primary haemostatic failure/.
Thrombocytopenia
Causes of multiple clotting factor deficiences
DIC
Liver disease
Vit K deficiency/Warfarin
What would screening tests show if there was a multiple factor deficiency?
PT & APTT prolonged
Where is Vit K absorbed?
Upper intestine
What is required for Vit K absorption?
Bile salts
Causes of Vit K deficiency
Poor dietary intake Malabsorption Obstructive jaundice Vit K antagonists Haemorrhagic disease of the newborn
What is DIC?
Excessive and inappropriate activation of the haemostatic system
Causes of DIC
Sepsis
Placental abruption
Malignancy
Hypovolaemic shock
How is haemophilia transmitted?
X-linked
