Lymph node pathology

Question 1

What characterizes non-specific benign follicular hyperplasia?

Answer 1

(1) Preservation of lymph node architecture
(2) Marked variation of follicles
(3) Presence of frequent mitosis and phagocytic macrophages

Question 2

What patterns are seen in HIV lymphadenopathy?

Answer 2

(1) Follicular hyperplasia
(2) Follicular involution
(3) Lymphocyte depletion

Question 3

How is infectious mononucleosis diagnosed?

Answer 3

EBV titer IgM and IgG

May resemble lymphoma, some cells look like Reed-Sternberg cells (owl eye cells) found in Hodgkin Lymphoma

Question 4

What is lymphoma?

Answer 4

Neoplastic proliferation of lymphoid tissue

Question 5

What three viruses can cause lymphoma?

Answer 5

(1) EBV
(2) HTLV-1
(3) HHV-8 (Kaposi sarcoma herpes virus)

Question 6

What are three differences between small and large cell lymphoma?

Answer 6

(1) SCL - indolent, LCL - aggressive
(2) SCL - disseminated, LCL - localized
(3) SCL - incurable, LCL - curable

Question 7

What chromosomal translocation causes follicular lymphoma?

Answer 7

t(14;18) - BCL2 and IgH genes translocated

Question 8

What are the histogical characteristics of follicular lymphoma?

Answer 8

(1) Disruption of normal lymph node architecture by neoplastic follicles
(2) Lack of tingible body macrophages due to absence of apoptosis

Question 9

What translocation causes mantle cell lymphoma?

Answer 9

t(11;14) - cyclin D1 and IgH genes translocated, leading to constitutive transition from G1 to S phase of cell cycle