Lyme Disease

Question 0

The spirochete causing Lyme disease:

Answer 0

Borrelia burgdoferi

Question 1

Give the genus of the vector for Lyme disease.

Answer 1

Ixodes (ticks)

Question 2

B. burgdoferi stains well with:

Answer 2

Giemsa or Wright

Question 3

It is the largest medically important bacteria:

Answer 3

Borrelia burgdoferi

Question 4

3 bacterial shapes:

Answer 4

Cocci (spheres)
Bacilli (rods)
Spirochetes (spirals)

Question 5

Culture for B. Burgdoferi:

Answer 5

Barbour-Stoenner-Kelly medium

Question 6

Animal reservoirs for B. Bugdorferi:

Answer 6

White-footed mouse

White-tailed dear

Question 7

Transmission to host is via:

Answer 7

Bite from Ixodes scapularis (deer tick)

Question 8

The term preference for habitat:

Answer 8

Tropism

Question 9

Considered the pathognamonic sign of this disease:

Answer 9

Erythema migrans

Question 10

3 distinct morphologies of Erythema migrans:

Answer 10

Dark center of small papule, vesicle, or bulba
Pale intermediate zone
Peripheral rim of erythema

Question 11

Known as target lesion or iris lesion that appears 7-14 days after tick is removed:

Answer 11

Erythema migrans

Question 12

The atrophy and thinning of skin (as thin as cigarette paper) and is more common in Europe:

Answer 12

Acosermatitis chronicum atrophicans

Question 13

The phase that exhibuts flu-like symptoms:

Answer 13

Early lyme disease (w/in 30 days of bite)

Question 14

Characteristic muskuloskeletal and neurologic symptoms together with cardiac and dermatologic symptoms occur during what phase?

Answer 14

Early disseminated lyme disease

Question 15

Observed months to years after infection with the joints and neurologic system most commonly affected:

Answer 15

Late or chronic lyme disease

Question 16

4 characteristic symptoms of lyme disease:

Answer 16

Bell’s palsy
Arthritis
Cardiac block
Erythema chronicum migrans

Question 17

The tetracycline drug most commonly used for treatment of Lyme disease:

Answer 17

Doxycycline

Question 18

Doxycycline inhibits bacterial _________ __________ by binding & interfering with ribosomes.

Answer 18

Protein synthesis

Question 19

Penicillins and cephalosporins are examples of ________________ that inhibit peptidoglycan synthesis.

Answer 19

Cell wall inhibitors

Question 20

It is the polysaccharide component of cell wall.

Answer 20

Peptidoglycan

Question 21

Quinolones are examples of:

Answer 21

DNA synthesis inhibitors

Question 22

1 svedberg unit is equivalent to how many seconds:

Answer 22

10^-13 seconds

Question 23

Protein synthesis inhibitors act on ribosomes to inhibit what?

Answer 23

Translation

Question 24

A high-end drug that is used as a last resort antibiotic.

Answer 24

Linezolid

Question 25

Mechanism of action of linezolid:

Answer 25

Inhibits union of 50s ans 30s (formation of initiation complex)

Question 26

What do aminoglycosides do? (30s inhibtors)

Answer 26

Stop initiation of translation Incorporation of false amino acid Premature termination of translation

Question 27

Inhibits 50s:

Answer 27

Macrolides Lincosamides Chloramphenicol

Question 28

Drug that is specific for 50s and may treat all type of infection but cause aplastic anemia.

Answer 28

Chloramphenicol

Question 29

Inhibit translocation:

Answer 29

Erythromycin Clindamycin (Macrolides and lincosamides)

Question 30

Bind to 30s subunit thus preventing aminoacyl-tRNA binding to ribosome:

Answer 30

Tetracycline