LW3 Flashcards
Causes of myocarditis
Viral (coxsachie: heart foot and mouth), Bacterial (meningococcus), Radiation, Drugs
How do fibrinolytics work
converts plasminogen to plasmin which breaks down fibrin and so dissolves thrombi
What bleeds do you get in haemophilia?
haemarthroses, haematuria, intramuscular , intracranial
Treatment of haemophilias+von willebrand?
DDAVP (only in A+vWF), factor concentrates, tranaxemic acid,
Investigations for haemorrhagic disorder
FBC, renal function, LFTs, Paraproteins
can also do factor assays, mixing studies etc
Causes of long PT
Warfarin, vit K deficiency, liver dysfn, Factor 7 def
Causes of long APTT
Haemophilia, von willebrand, Lupus anticoagulant, heparin
PT + APTT pattern in Vit K deficiency
^^PT and ^APTT
Causes of acquired bleeding disorders
Vit K def, Vit C def (affects collagen synthesis), DIC, Liver disease, acquired haemophilia
Acquired haemophilia pathophys
Spontaneous low factor 8 inhibitor which causes a very long APTT confirmed with inhibitor assay
Acquired haemophilia treatment
FEIBA, Novoseven, steroids, DDAVP, rituximab
Wiskott Aldrich Syndrome
hereditary thrombocytopaenia and eczema
Cause of bacterial endocarditis in neonates and in adults?
staph aureus in neonates and strep viridans
Causative organism for myocarditis?
adenovirus
Causes of congenital heart disease
TORCH, chromosomal abnormalities