Lutheran, MNS Flashcards
What are the three Lutheran null types?
In(Lu)
LuLu
XS2
What is the In(Lu) phenotype?
Inhibitor of Lutheran.
Autosomal dominant suppressor gene, EKLF/KLF1 that prevents normal erythroid transcription factor expression of inherited Lutheran genes and antigens.
EKLF=Erythroid Kruppel-like Factor.
50% of offspring inherit the dominant gene.
Parent can pass normal Lutheran genes to offspring.
Weak expression of Lutheran antigens is found.
Adsorption/Elution studies show trace amount of Lu antigens.
No Lutheran system antibodies are made.
P1, i, Aua, Inb An(Wj) and other red blood cell antigens are also depressed.
What is the LuLu phenotype?
Autosomal recessive inheritance of amorphic genes at Lu locus.
Not seen in successive generations.
Cannot pass normal Lu genes to offspring.
Red cells lack all Lutheran antigens.
Person is able to produce Lutheran system antibodies (Anti-Lua, Anti-Lub, Anti-Lu3).
What is the XS2 phenotype?
X-linked recessive inheritance.
XS1-Normal gene
XS2-Inhibitor gene
XS2 is a mutation in the major erythroid transcription factor, GATA-1
Weakened expression of Lutheran system antigens.
Increased i antigen expression
Red cells type as Lutheran antigen negative, but can adsorb/elute Lutheran antibodies.
No Lutheran system antibodies are made.
All Lunull of this type are male.
Phenotype is found in one family in Australia.
Prevalence of Lub
98.9%
Prevalence of Lua
8% in whites
5% in blacks
Antibody detection cells will not routinely detect with antibody specificity?
a. Anti-M
b. Anti-Kpa
C. Anti-Fya
d. Anti-Lub
b. Anti-Kpa
Antibodies to antigens in which of the following groups are known for showing dosage?
a. I
b. P
c. Kidd
d. Lutheran
c. Kidd
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
a. Anti-s
b. Anti-k
c. Anti-Lua
d. Anti-Jka
d. Anti-Jka
Pk antigen is related to what medical condition?
Spontaneous abortions
What Lutheran antigen does not have an antithetical pair?
a. Lu3
b. Lu6
c. Lu18
Correct: a. Lu3
