Lung Hypersensitivity

Question 1

What is a hypersensitivity reaction?

Answer 1

An undesirable reaction produced by the immune system

Question 2

What is the Gell and Coombs classification used for?

Answer 2

Describing the 4 types of hypersensitivity reaction

Question 3

What causes a Type 1 and Type 2 HS reaction? (2)

Answer 3

1) Allergies e.g. pollen, cat hair and Anaphylaxis

2) Transplant rejection/transfusion mismatch

Question 4

What causes a Type 3 and Type 4 HS reaction?

Answer 4

3) Fungal Reaction

4) TB

Question 5

What happens in timing for a HS reaction as go from 1–>4

Answer 5

The longer it takes for the reaction to appear

Question 6

What is atopy?

Answer 6

Genetic tendency to develop allergic disease

Question 7

Describe the mechanism of a T1 HSR?

Answer 7

Immunological memory causes allergic response, IgE AB bind to mast cells, causing a release in histamine

Question 8

Describe mechanism of T2 HSR?

Answer 8

Immunoglobulins bind to surface antigens

Question 9

Describe mechanism of T3 HSR?

Answer 9

Immune (Ant-AB) complexes occur, with activation of a complement

Question 10

Describe mechanism of T4 HSR?

Answer 10

T cell mediated immune response

secondary response of Granuloma of T cells and macrophages

Question 11

What are 5 antibody types?

Answer 11

IgG, IgA, IgM, IgE, IgD

Question 12

What is asthma defined as?

Answer 12

Airway hyper-reactivity as a variable reaction with airway inflammation

Question 13

What can asthma be described as? (2)

Answer 13

1) Extrinsic: Atopy/Long term exposure (occupational)

2) Intrinsic: Aspirin sensitive, late onset