Autonomic Regulation of the airways

Question 1

How is the airway regulated and what by?

Answer 1

1) Smooth muscle by Autonomic NS

2) Contract and relax airway diameter

Question 2

How does Autonomic NS regulate smooth muscle?

Answer 2

Contractile signals increase in intracellular calcium in smooth muscle, activate actin-myosin contraction (Reg by inflammation)

Question 3

What is lungs PS NT?

Answer 3

Acetylcholine

Question 4

What is lungs S NT?

Answer 4

Noradrenaline

Question 5

What does Ach do to pulmonary vessels?

Answer 5

Bronchoconstriction and vasodilation

Question 6

How PS Bronchoconstriction occur?

Answer 6

VN terminates in PS ganglia, short P-S NF reach muscle and release Ach which acts on muscarinic receptors

Question 7

Drugs which prevent BC?

Answer 7

Anti-cholinergics/muscarinics

Question 8

What do S/LAMAs do?

Answer 8

Increase bronchodilation and relieve breathlessness

Question 9

How does S Bronchorelaxation occur?

Answer 9

NA released activating adrenergic receptors (A/B), which causes activation of B2 receptors on smooth airway muscle causing muscle relaxation

Question 10

What do S/LABAs do?

Answer 10

Prevent bronchoconstriction

Question 11

What does activation of B2 agonist do?

Answer 11

Activate AC, ^ Intracellular cAMP, causing airway smooth muscle relaxation