Lung cancer: Paraneoplastic features

Question 1

Lung cancer: paraneoplastic features:Small cell?

Answer 1

• ADH
• ACTH - not typical, hypertension, hyperglycaemia, hypokalaemia, alkalosis and muscle weakness are more common than buffalo hump etc
• Lambert-Eaton syndrome

Question 2

Lung cancer: paraneoplastic features:Squamous cell?

Hypertrophic pulmonary osteoarthropathy is a proliferative periostisis involving that typically involves the long bones. It is often painful.

Answer 2

• parathyroid hormone-related protein (PTH-rp) secretion causing hypercalcaemia
• clubbing
• hypertrophic pulmonary osteoarthropathy (HPOA)
• hyperthyroidism due to ectopic TSH

Question 3

Lung cancer: paraneoplastic features: Adenocarcinoma?

Answer 3

• gynaecomastia