Lung Cancer And Tobacco Flashcards

1
Q

If lung cancer is suspected by a GP, what is the maximum wait time to see to lung clinic?

A

2 week wait

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2
Q

Which cancer has the highest number of deaths worldwide?

A

Lung cancer

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3
Q

Name the cancers that are the biggest killers

A
Lung 
Colorectal 
Breast 
Prostate 
Oesophagus 
Pancreas
Stomach
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4
Q

Which 3 cancers have the worst 5 year survival rates?

A

Pancreas
Lung
Leukaemia

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5
Q

What is an MST?

A

Median survival time

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6
Q

Why has lung cancer got an increased incidence in poorer communities?

A

More likely to smoke
Less access to health care
Less likely to seek help
English may not be first language

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7
Q

What is the commonest age group to get lung cancer?

A

60 - 80 years old

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8
Q

Tobacco smoking is linked to what proportion of all cancer deaths?

A

1/3

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9
Q

Apart from smoking, name some other lung cancer risk factors

A

Radon
Asbestos
Occupational carcinogens (nickel)
Genetic factors

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10
Q

List the criteria needed for an effective screening

A
Disease with serious consequences
High prevalence of detectable disease
Test detects little pseudo-disease
Test detects disease before critical point
Test causes little morbidity 
Affordable and available 
Treatment exists 
Treatments is more effective when applied before symptom detection 
Treatment not too risk or toxic
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11
Q

What percentage of people presenting with lung cancer actually have a treatable disease?

A

20%

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12
Q

Describe the basis of TNM staging

A
T = tumour
N = lymph nodes 
M = metastases
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13
Q

Where does lung cancer spread locally?

A

Draining lymph nodes
Pleura
Pericardium

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14
Q

Where does lung cancer commonly spread to distally?

A

Brain
Liver
Adrenals
Bone

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15
Q

When staging lung cancer, what imagining techniques do we use?

A

CXR
CT scan
PET scan
(Consider MRI, USS, bone scan, ECHO)

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16
Q

How does a PET scan work?

A

Shows areas of increased activity (metabolism) in a tissue
(Glows orange)
We can figure out if lymph nodes are enlarged due to cancer or another reason

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17
Q

Other than cancer, name 2 lung conditions which in cause tissue to be overactive

A

Pneumonia

Sarcoidosis

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18
Q

Name some techniques for getting a tissue sample from the lungs

A
Bronchoscopy 
USS guided 
CT guided 
Thoracoscopy
Surgical
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19
Q

Give some symptoms of a primary lung tumour

A
Cough 
Dyspnoea 
Wheezing 
Haemoptysis 
Lung infection 
Chest/shoulder pain 
Weight loss
Lethargy/malaise
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20
Q

What is the commonest presentation of lung cancer?

A

No symptoms

21
Q

Give some symptoms that indicate regional metastases of lung cancer

A
Bloated face (SVC obstruction)
Hoarseness of voice
Dyspnoea 
Dysphagia 
Chest pain
22
Q

Give some symptoms that indicate distant metastases of lung cancer

A
Bone pain or fracture 
CNS symptoms 
Hypercalcaemia
Hyponatraemia 
Seizures 
Thirst and constipation
23
Q

Give some clinical signs of lung cancer

A
Finger clubbing 
SVC obstruction 
Cachexia 
Pale conjunctiva
Cervical lymphadenopathy 
Horner's syndrome 
Consolidation 
Signs of pleural effusion 
Muffled heart sounds
Liver enlargement 
Skin metastases
24
Q

What is Horner’s syndrome?

A

Pressing on the sympathetic trunk causing:
Miosis (constriction of pupil)
Ptosis (weak, droopy eyelids)
Anhidrosis (decreased sweating)

25
Name the endocrine paraneoplastic syndromes that can occur with lung cancer
Hypercalcaemia Cushing's SIADH
26
Give some neurological paraneoplastic syndromes that can occur with lung cancer
Encephalopathy Peripheral neuropathy Eaton-lambert
27
Give some haematological paraneoplastic syndromes that can occur with lung cancer
Anaemia | Thrombocytosis
28
Where do we usually do a biopsy for lung cancer?
In a regional lymph node | Confirm if it is cancer and has it spread
29
What is the most common type of lung cancer?
Non-small cell carcinoma
30
What are the different types of non-small cell carcinoma?
Squamous cell carcinoma Adenocarcinoma Large cell carcinoma
31
What are the 2 most common specific lung cancers?
Squamous cell carcinoma (40%) | Adenocarcinoma (35%)
32
What are the main types of lung cancer?
Non-small cell | Small cell
33
What are molecular markers?
Genetic mutations in some tumours that we can target therapy at
34
Why does performance status in a cancer patient need to be assessed?
Decide whether they will be able to cope with the treatment | Treatment is very exhausting
35
Describe the performance status ranking
``` 0 = no symptoms, normal activity 1 = symptomatic but able to carry out normal daily activities 2 = symptomatic, in bed or chair less than half the day. Needs some assistance with daily activities 3 = symptomatic, in bed or chair more than half the day 4 = bedridden 5 = dead ```
36
What performance status is required to consider cancer treatment?
< 2
37
What are the different treatment options for lung cancer?
``` Surgery Radiotherapy - radical (curative intentions) or palliative Chemotherapy Combined chemo and radio Targeted therapies Palliative care ```
38
What type of lung cancer are we most likely to attempt surgery on?
Non small cell
39
Chemotherapy can potentially be curative for which type of lung cancer?
Small cell
40
Has the general prevalence of smoking increased or decreased?
Decreased
41
In which groups of people have the prevalence of smoking remained the same?
Unemployed Prisoners People with mental health issues
42
Name some of the many tobacco related diseases
``` Lung cancer COPD Mouth cancer Atherosclerosis Stroke Aneurysm Claudication RA Dementia Cancers: throat, renal, bladder, pancreatic etc ```
43
What are markers of addiction?
Use despite knowledge of harmful consequences Cravings during abstinence Failure of attempts to stop Withdrawal symptoms during abstinence
44
Why is nicotine addictive?
Acts on nicotinic acetylcholine receptors (nAChR) Stimulates dopamine release Gives satisfaction
45
What happens in chronic nicotine exposure?
Upregulated nAChRs | Therefore a decline in nicotine will cause withdrawal symptoms and cravings
46
What is the difference between patch and spray nicotine replacements?
Patch - constant nicotine source | Spray - hit of nicotine like when smoking
47
What are the 3 As of helping people to stop smoking?
Ask - about smoking status Advise - health benefits of stopping Act - build confidence, give into, refer, prescribe
48
What are Champix?
Nicotine gum Partial nicotine agonist with high affinity Reduces cravings and reduces withdrawal symptoms Also reduces the satisfaction a smoker will get from smoking