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Oncology G > Lung Cancer > Flashcards

Lung Cancer Flashcards

1
Q

Does small cell cause clubbing ?

A

No

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2
Q

What is the main RF for SCLC?

A

Smoking - almost all patients are smokers

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3
Q

What are poor prognostic markers of SCLC?

A

Extensive diseases Poor ECOG Hyponatraemia Elevated ALP and LDH

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4
Q

What is limited stage SCLC?

A

One hemithorax - e.g. hilar, mediastonal and subclavicular LN

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5
Q

What is extensive stage SCLC?

A

Spread beyond hemithorax - ipsilateral effusion or mets

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6
Q

Treatment of limited SCLC?

A

Concurrent chemo/radio

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7
Q

Treatment of extensive SCLC?

A

Chemo - carbo/etop

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8
Q

What are the 2 main RF for mesothelioma?

A

Asbestos and Tabacco

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9
Q

Treatment of mesothelioma?

A

Resect - uncommonly done due to high mortality procedure Chemo with cisplatin and permetrexed - Poor prognosis

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10
Q

What investigations are done for staging of NSCLC?

A
  • WBBS - CT brain, chest, abdo, pelvis - PET ( often pick up mets and upstages cancer)
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11
Q

What are types of lung cancer?

A

Adenocarcinoma Squamous Small Cell Large cell Bronchoalveolar

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12
Q

What is stage 1 NSCLC?

A

under 5 cm

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13
Q

What is stage 2 NSCLC?

A

Local spread, can be to pleura or chest wall, can have local LN

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14
Q

What is stage 3 NSCLC?

A

LN in mediastinum or ipsilateral lung nodules

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15
Q

What is stage 4 NSCLC?

A

Mets or malignant effusion

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16
Q

How do you manage stage 1 NSCLC?

A

Resect

17
Q

How do you manage stage 2 NSCLC?

A

Resect Adjuvant chemo - cisplatin + vinorebline

18
Q

How do you manage stage 3 NSCLC?

A
  1. Resect 2. If unresectable - neoadjuvant chemo to downsize 3. Combined chemo radiotherapy
19
Q

How do you manage stage 4 NSCLC?

A
  1. ALK + EGFR + ROS-1 Mutation

If positive

  • eGFR - erlotinib, gefetonib
  • ALK - crizotonib
  • ROS-1 Crizotonib

If negative

  • chemo (cis/carbo-platin + any of vinorebline/paclitaxal, gemcitabine)
    2. Pembro/Nivo 2nd line
20
Q

What diver mutations are associated with NSCLC?

A

eGFR, ALK, ROS-1

21
Q

What phenotype gets eGFR mutations?

A

young, asian, female, never smoker with adenocarcinoma

Oncology G (8 decks)

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