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Oncology G > Cytotoxics > Flashcards

Cytotoxics Flashcards

1
Q

Alkylators examples ?

A 
Cyclophophamide 
Ifosphamide
Temozolamide (crosses BBB)
Busulfan
Chlorambucil
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2
Q

MOA of Alkylators ?

A

Alkylates DNA forming covalent bonds.

This interferes with DNA replication and transcription

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3
Q

Side effects of cyclophosphamide?

A

Haemorrhagic cystitis and bladder TCC

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4
Q

Plantinum analogues examples (3) ?

A
  • platins

Carbo, cis, oxali

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5
Q

MOA of platinums ?

A

DNA cross linking

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6
Q

AE of platinums

A

Neurotoxicity, nephrotoxicity, ototoxicity

Very emetogenic

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7
Q

Antimetabolites examples ?
purine
folate
pyrimidine

A

Pyrimidine - 5-flurouricil, Capcitabine(oral 5-FU prodrug), Gemcitabine, Cytarabine
Purines- 6 Mecaptopurine, Azathioprine, fludarabine,
Folate - Methotrexate, permetrexed

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8
Q

Methotrexate AE (specific)?

A

Pulmonary fibrosis

Hepatotoxicity

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9
Q

5 -FU AE?

A

Hand and foot syndrome
Diarrhoea
Mucositis

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10
Q

Topoisomerase Inhibitors examples 1 and 2 ?

A

TI 1 = Irinotecan , Topetecan

TI 2 = Etoposide

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11
Q

Topoisomerase inhibitors MOA ?

A

Topoimerases hold DNA in coiled position and allows transcription and replication

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12
Q

Anthracyclines examples?

A

-Rubicin

doxo, dauno, ida, epi

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13
Q

MOA anthracyclines?

A
  • Antitopoimerase activity

- Prevents RNA and DNA synthesis

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14
Q

Anthracycline AE?

A

Cardiac toxicity

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15
Q

Bleomycin MOA?

A

Degrades pre-formed DNA

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16
Q

AE Bleomycin?

A

Pulmonary fribrosis, reynauds, skin change (smallest acount of hydrolayse which degrade bleomycin in skin and lung)

17
Q

Anti microtubules Taxane examples?

A
  • taxals

Pacli, Docetaxal, Abraxane (pacli bound to albumin)

18
Q

Anti- microtubules Vinca examples ?

A
  • vincas

Vincristine, vinblastine, vinorelbine

19
Q

AE vinca anti-microtubules?

A

Skin necrosis ( or death if given IT), neuropathy

20
Q

Which cytotoxic agents can cause AML?

A
  1. Alkylating agents
  2. Topoimerase II agent - e.g. etoposide
  3. Anthracyclines - doxorubicin
21
Q

Which cytotoxics cause renal ipairment ?

A

Ifosfamide and cisplatin

22
Q

Which cytotoxic agent causes infertility ?

A
  1. Alkylating agents
23
Q

Which agents cause palmer planter syndrome?

A

5-FU, capecitabine, Sunitinib, sorafenib, docetaxal

24
Q

Which cancer agents can cause cardiac AE ?

A
  1. Anthracyclines - irreversible
  2. Trastuzimab - reversible
  3. 5-FU/ Capecitabine cause coronary vasospams
  4. Sunitinib, sorafenib and Bevacizumab cause Hypertension
25
Q

Which cancer agents cause Pulmonary AE?

A
  1. Bleomycin - irreversible interstitial pulmonary fibrosis
  2. Evorolimus - pneumonitis
  3. Erlotinib/gefitinib - ILD
26
Q

What cancer agents cause neurotoxicity ?

A
  1. Platinums - acute cold induced paresthesia, chronic is glove and stocking
  2. Taxanes (-taxal) glove and stocking
  3. Vincristine

Oncology G (8 decks)

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